Results 201 to 210 of about 983,966 (332)

Optimizing Angiopep‐2 Density on Polymeric Nanoparticles for Enhanced Blood–Brain Barrier Penetration and Glioblastoma Targeting: Insights From In Vitro and In Vivo Experiments

Advanced Functional Materials, EarlyView.
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang, Ahmed Refaat, Haoqin Li, Douer Zhu, Ziqiu Tong, Joseph Anthony Nicolazzo, Bo Peng, Hua Bai, Lars Esser, Nicolas Hans Voelcker   +9 more
wiley   +1 more source

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source

Exploring the impact of mobile and migrant populations on mass drug administration coverage and effectiveness in Africa: A scoping review protocol. [PDF]

PLoS One
Sangare M, Coulibaly YI, Ravichandran P, Diabate AF, Duguay C, Vlassoff C, Kulkarni MA, Krentel A.   +7 more
europepmc   +1 more source

Trends of Coverage of Mass Drug Administration, Population at Risk and Reported Cases of Schistosomiasis and Soil-Transmitted Helminths, Uganda, 2013-2023. [PDF]

BMC Infect Dis
Namara BG, Kwesiga B, Migisha R, Bulage L, Tinkitina B, Ario AR, Mubangizi A.   +6 more
europepmc   +1 more source

Economic Evaluations of Mass Drug Administration: The Importance of Economies of Scale and Scope [PDF]

, 2017
Hugo C. Turner, Jaspreet Toor, T. Déirdre Hollingsworth, Roy M. Anderson   +3 more
openalex   +1 more source

Strategies to Design and Optimize Artificial Antigen‐Presenting Cells for T Cell Expansion in Cancer Immunotherapy

Advanced Functional Materials, EarlyView.
This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley   +1 more source

Evolutionary dynamics in the genome of ocular <i>Chlamydia trachomatis</i> strains from Northern Tanzania following mass drug administration. [PDF]

Microb Genom
Ghasemian E, Ramadhani A, Harte A, Mafuru E, Derrick T, Mtuy T, Massae P, Malissa A, Breuer J, Pickering H, Bailey RL, Mabey D, Burton MJ, Holland MJ.   +13 more
europepmc   +1 more source

Costs of Testing for Ocular Chlamydia trachomatis Infection Compared to Mass Drug Administration for Trachoma in The Gambia: Application of Results from the PRET Study

, 2015
Emma M. Harding‐Esch, Mireia Jofre‐Bonet, Jaskiran K. Dhanjal, Sarah E. Burr, Tansy Edwards, Martin J. Holland, Ansumana Sillah, Sheila K. West, Tom Lietman, Jeremy D. Keenan, David Mabey, Robin L. Bailey   +11 more
openalex   +2 more sources

Effect of generalised access to early diagnosis and treatment and targeted mass drug administration on Plasmodium falciparum malaria in Eastern Myanmar: an observational study of a regional elimination programme [PDF]

, 2018
Jordi Landier, Daniel M. Parker, Aung Myint Thu, Khin Maung Lwin, Gilles Delmas, François Nosten, Chiara Andolina, Ricardo Águas, Saw Moe Ang, Ei Phyo Aung, Naw Baw Baw, Saw Aye Be, Saw B'Let, Hay Bluh, Craig Bonnington, Victor Chaumeau, Miasa Chirakiratinant, Win Cho Cho, Peter Christensen, Vincent Corbel, Nicholas Day, Saw Hsa Dah, Gilles Delmas, Mehul Dhorda, Arjen M. Dondorp, Jean Gaudart, Gornpan Gornsawun, Warat Haohankhunnatham, Saw Kyaw Hla, Saw Nay Hsel, Gay Nay Htoo, Saw Nay Htoo, Mallika Imwong, Saw John, Ladda Kajeechiwa, Lily Kereecharoen, Praphan Kittiphanakun, Keerati Kittitawee, Kamonchanok Konghahong, S D Khin, Saw Win Kyaw, Jordi Landier, Clare Ling, Khin Maung Lwin, Khine Shwe War Lwin, Naw K' Yin, Alexandra Marié, Cynthia Maung, E Marta, Myo Chit Minh, Olivo Miotto, Paw Khu Moo, Ku Ler Moo, Merry Moo, Naw Na Na, Mar Nay, François Nosten, Suphak Nosten, Slight Naw Nyo, Eh Kalu Shwe Oh, Phu Thit Oo, Tun Pyit Oo, Daniel M. Parker, Eh Shee Paw, Choochai Phumiya, Aung Pyae Phyo, Kasiha Pilaseng, Stéphane Proux, Santisuk Rakthinthong, Wannee Ritwongsakul, Kloloi Salathibuphha, Armon Santirad, Sunisa Sawasdichai, Lorenz von Seidlein, Paw Wah Shee, Paw Bway Shee, Decha Tangseefa, Aung Myint Thu, May Myo Thwin, Saw Win Tun, Chode Wanachaloemlep, Lisa J. White, Nicholas J. White, Jacher Wiladphaingern, Saw Nyunt Win, Nan Lin Yee, Daraporn Yuwapan   +86 more
openalex   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source