Results 191 to 200 of about 687,738 (249)

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Acceptability of mass drug administration for lymphatic filariasis in Baglung Municipality of Nepal: A mixed-method study. [PDF]

PLOS Glob Public Health
Pudasainee M, Paneru DP, Acharya B, Sharma P, Khanal A, Rana B, Adhikari S, Adhikari C.   +7 more
europepmc   +1 more source

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

Advanced Healthcare Materials, EarlyView.
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith   +7 more
wiley   +1 more source

An integrated mass drug administration against hymenolepiasis and schistosomiasis in Sudan. [PDF]

Parasites Hosts Dis
Jin Y.
europepmc   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Lessons from piloting and scaling a real-time DHIS2 based treatment reporting tool for mass drug administration in Nigeria. [PDF]

PLoS Negl Trop Dis
Imhansoloeva M, Nwosu C, Osinoiki O, Isiyaku S, Anyaike C, Amodu-Agbi P, Egbelu U, Nwoye A, Oyinloye P, Abdurahman AU, Otiji I, Nweke L, Kumbur J, Ishaya R, Dixon R, Bartlett S.   +15 more
europepmc   +1 more source

Copper–Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids

Advanced Healthcare Materials, EarlyView.
Ionic copper is investigated as a modulator of tumor spheroid growth and invasiveness in a 3D microfluidic glioblastoma model. Copper exposure alters metabolic activity, cytoskeletal organization, protrusion dynamics, and EMT‐related phenotypes in a dose‐ and timing‐dependent manner, revealing how copper bioavailability shapes tumor aggressiveness ...
Paula Guerrero‐López, Jose I. Garcia‐Peiro, Felipe Hornos, Jose L. Hueso, Jesus Santamaria, J. Manuel Garcia‐Aznar   +5 more
wiley   +1 more source

How improvements to drug effectiveness impact mass drug administration for control and elimination of schistosomiasis. [PDF]

PLoS Negl Trop Dis
Ellis JR, Mutono N, Vasconcelos A, Thumbi SM, Hollingsworth TD, Anderson RM.   +5 more
europepmc   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Azithromycin mass drug administration to reduce child mortality in Niger (AVENIR II): a master protocol for a cluster-randomized adaptive platform trial to evaluate community-based health interventions. [PDF]

Trials
Arzika AM, Amza A, Ousmane S, Maliki R, Almou I, Galo N, Harouna N, Mankara A, Aichatou B, Boubacar O, Lebas E, Peterson B, Brandt C, Picariello A, Cheng A, Porco TC, Doan T, Arnold BF, Lietman TM, O'Brien KS.   +19 more
europepmc   +1 more source