Results 101 to 110 of about 11,477,062 (289)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Flow dynamical behavior and performance of a micro viscous pump with unequal inlet and outlet areas

Engineering Applications of Computational Fluid Mechanics, 2016
The micro viscous pump is an important type of fluidic device. Optimizing the working performance of the pump is crucial for its wider application. A micro viscous pump design with unequal inlet and outlet areas is proposed in this paper.
Chenhui Hu, Wei Wu, Jibin Hu, Shihua Yuan   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Mass flow rates in and outflow rates from AGN accretion discs

, 2012
We derive analytical expressions for the mass flow rates in and from accretion discs, taking into account the Eddington limit. This allows us to connect the basic properties of outflows with those of the accretion flow. As an example, we derive the radial surface density distribution in the accretion disc of Mrk 231.
Blank, Marvin, Duschl, Wolfgang J.
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Virtual Refrigerant Mass Flow and Power Sensors for Variable-Speed Compressors [PDF]

, 2012
The use of variable-speed compressors in heat pumps and air conditioners has increased in recent years in order to improve comfort and energy efficiency.
Kim, Woohyun, Braun, James E.
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

On the measurement of the mass flow rate of horizontal two-phase flows in the proximity of the transition lines which separates two different flow patterns

, 2015
A venturi nozzle coupled with a capacitive holdup meter was tested to measure the gas-liquid mass flow rate. An experimental facility was built and operated with air-water mixtures.
dos Reis, E, Goldstein, L
core   +1 more source

Web-based Operation of Mass Flow Rate Measuring Instruments

International Journal of Online and Biomedical Engineering (iJOE), 2007
The paper introduces a solution for a web-based operation of mass flow rate measuring instruments (LeanTMF-Net). The system is based on Ethernet link moduls for HART process data and an event-based real- time web-visualization The LeanTMF-Net can be flexibly adapted to the relevant user conditions thanks to the transparent and user-independent ...
openaire   +2 more sources