Results 171 to 180 of about 26,667,629 (348)

[Mibefradil improves skeletal muscle mass, function and structure in obese mice]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao, 2022
Wu J, Wu Y, Yang Y, Yu J, Fu R, Sun Y, Xiao Q.   +6 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Targeting SCAMP2 by a natural product auxarconjugatin B for glioblastoma therapy via restoring aspartate metabolic flux

Acta Pharmaceutica Sinica B
Glioblastoma (GBM), the most aggressive primary brain malignancy, presents an urgent need for novel therapeutic targets addressing metabolic reprogramming in tumor progression.
Changhui Shang, Wan Li, Qianlun Pu, Bingyu Liu, Chen Zhang, Yiqing Tan, Yihui Yang, Dan Du, Jinhua Wang, Youcai Hu   +9 more
doaj   +1 more source

Towards accurate rescaling of a halo mass function

Open Astronomy, 2018
We investigate the precision within which a simulated dark matter halo mass function can be rescaled to a different set of cosmological parameters. Our tests show that the accuracy almost linearly depends on the difference of the cosmological parameters ...
Yankelevich Victoria, Pilipenko Sergey V.   +1 more
doaj   +1 more source

Mass Spectrometric Detection of Cholesterol Oxidation in Bovine Sperm [PDF]

, 2011
We report on the presence and formation of cholesterol oxidation products (oxysterols) in bovine sperm. Although cholesterol is the most abundant molecule in the membrane of mammalian cells and is easily oxidized, this is the first report on cholesterol ...
Gadella, B.M., Biology of Reproductive Cells, da Silva, P.F.N., van Gestel, R.A., Tissue Repair, Brouwers, J.F.H.M., Boerke, A., Helms, J.B., Dep Biochemie en Celbiologie, Biomolecular Mass Spectrometry and Proteomics, Sub Biomol.Mass Spect. and Proteomics, Garcia-Gil, N., Dep Gezondheidszorg Landbouwhuisdieren, van de Lest, C.H.A.   +13 more
core   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Substellar initial mass function of Trumpler 14

Astronomy & Astrophysics
Context. Young, massive stellar clusters offer a prime setting to explore brown dwarf (BD) formation under high densities and intense UV radiation. Trumpler 14 (Tr 14), a ∼1 Myr old cluster located at a distance of 2.4 kpc that is particularly rich in O ...
Rom T., Moraux E., Mužić K., Andersen M., Schirmer M., Almendros-Abad V.   +5 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source