Results 91 to 100 of about 4,471,573 (294)
MicroorganismsLitter decomposition dynamics are largely governed by microbial interactions. While the involvement of endophytic fungi in early-stage decomposition and microbial succession is well established, their species-specific contributions to decomposer ...
Dongmei Yang +4 more
doaj +1 more source
A Porosity-Length Formalism for Photon-Tiring-Limited Mass Loss from Stars Above the Eddington Limit
, 2004 We examine radiatively driven mass loss from stars near and above the Eddington limit (Ledd). We begin by reviewing the instabilities that are expected to form extensive structure near Ledd.
Gayley, Kenneth G. +2 more
core +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Construction MaterialsThis research study aims to enhance the understanding of corrosion behaviour in lapped spliced joints within reinforced concrete structures. Specifically, the effect of corrosion on bond degradation and crack formation is investigated.
Amged O. Abdelatif +6 more
doaj +1 more source
The Mass Function and Average Mass Loss Rate of Dark Matter Subhaloes
, 2005 We present a simple, semi-analytical model to compute the mass functions of dark matter subhaloes. The masses of subhaloes at their time of accretion are obtained from a standard merger tree. During the subsequent evolution, the subhaloes experience mass
Bosch, Frank C. van den +2 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source