Results 51 to 60 of about 1,854,261 (265)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Partitioning Recent Greenland Mass Loss [PDF]

Science, 2009
GRACE and Movement Together Recent measurements of the rate of mass loss from the Greenland ice sheet vary approximately by a factor of three. Resolving these discrepancies is essential for determining the current mass balance of the ice sheet and to project sea level rise in the future. Van den Broeke
van den Broeke, Michiel, Bamber, Jonathan, Ettema, Janneke, Rignot, Eric, Schrama, Ernst, van de Berg, Willem Jan, van Meijgaard, Erik, Velicogna, Isabella, Wouters, Bert   +8 more
openaire   +5 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Evolutionary effects of mass loss in low-mass stars [PDF]

International Astronomical Union Colloquium, 1981
AbstractThe effects of mass loss on the evolution of low-mass stars (actual mass smaller than 1.4 Mʘ) are reviewed. The case of globular cluster stars is discussed in some detail, and it is shown that evolutionary theory sets quite precise limits to the mass-loss rate in population II red giants.
openaire   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Mass conservation and rapid mass loss on the main sequence [PDF]

Symposium - International Astronomical Union, 1979
The rapid mass loss observed in O stars can affect their evolution dramatically if it takes place during core hydrogen burning on the main sequence. Conti has suggested that this is the case for the brightest Of stars, and that these stars evolve into Wolf-Rayet (WR) stars.
openaire   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

On the Consequences of Mass Loss from Intermediate-Mass Stars [PDF]

International Astronomical Union Colloquium, 1981
There are two major effects of mass loss from stars of intermediate mass. First, the ultimate fate of such stars--whether they become supernovae of the type that leave no condensed remnant or whether they become white dwarfs--is extremely sensitive to the rate at which they lose mass during the last portion of their nuclear-burning lives.
openaire   +1 more source

Pore pressure evolution and mass loss of broken gangue during the seepage [PDF]

Royal Society Open Science, 2018
Broken gangue consists of different particles, and it has more complicated seepage characteristics than intact rock sample. Using the self-designed instrument, the permeability, mass loss and pore pressure of crushed gangue during the seepage are tested.
Jixiong Zhang, Yu Liu, Nan Zhou, Meng Li   +3 more
doaj   +1 more source