Results 71 to 80 of about 1,053,987 (302)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

ANALYSES OF LANDSCAPE GEOGRAPHIC IMPACTS OF POTENTIAL CLIMATE CHANGE IN HUNGARY [PDF]

Acta Geographica Debrecina. Landscape & Environment Series, 2012
Change of climate can be a remarkable turning point in the 21st century history of mankind. An important task of landscape geographic research is forecasting environmental, nature protection, land use demands and helping mitigation of disadvantageous ...
PÉTER CSORBA, GÁBOR MEZŐSI, GABRIELLA SZÉPSZÓ, VIKTÓRIA BLANKA, BURGHARD C. MEYER, RÓBERT VASS   +5 more
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Monitoring and Assessing the Dynamics of Building Deformation Changes in Landslide Areas

Buildings, 2019
The paper presents the procedure and results of monitoring conducted by using a 3D measurement model, taking advantage of integrated surveying technologies developed for a building located within an activated landslide area.
Lucyna Florkowska, Izabela Bryt-Nitarska, Rafał Gawałkiewicz, Janusz Kruczkowski   +3 more
doaj   +1 more source

The movement of sediment in a channel in relation to magnitude and frequency concepts- a New Zealand example [PDF]

, 1970
In areas where surface wash contributes most of the debris to a channel network, the effect of events of moderate magnitude and frequency appear to be more important than catastrophic events for land form development.
Hosking, Peter L., Pain, C.F.
core   +1 more source

Underground railroads: citizen entitlements and unauthorized mobility in the antebellum period and today [PDF]

, 2010
In recent years, some scholars and prominent political figures have advocated the deepening of North American integration on roughly the European Union model, including the creation of new political institutions and the free movement of workers across ...
Archibold R. C., Blackett R. J.M., Bordewich F. M., Bordewich F. M., Brown H., Buchanan A., Cabrera L., Caney S., Carens J., Christie B., Clinton C., Coffin L., Ellingwood K., Eschbach K., Fox V., Franklin J. H., Graham O., Grossman D., Hadden S. E., Hayworth J. D., Hendricks T., Hoeffer M., Humez J., Huntington S., Innes S., Innes S., Kochhar R., Lowance M. I., Lucas R. E.B., Luis Cabrera, Manley J. P., McCombs B., Mitchell L. L., Moellendorf D., Pacheco J. F., Pastor R. A., Pastor R. A., Pickard M., Pogge T., Pollack A., Rawls J., Sen A., Still W., Tancredo T.   +43 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Evaluation of Mass Movement Hazard in the Shoreline of the Intertidal Complex of El Grove (Pontevedra, Galicia)

Remote Sensing
Knowledge of hazard conditions due to mass movements is one of the non-structural measures for risk management, urban planning, and protection of natural resources.
Joaquín Andrés Valencia Ortiz, Carlos Enrique Nieto, Antonio Miguel Martínez-Graña   +2 more
doaj   +1 more source

The Social Expulsion of the Migrant: Aesthetic and Tactical Interventions [PDF]

, 2017
In this article, I focus on the social expulsion of the migrant. Social expulsion refers to the multivalent ways in which those in power demean, vilify, exclude, displace, and strip people of hope for the future.
Pérez Miles, Adetty
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source