Results 111 to 120 of about 12,854,723 (342)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Nuclear Black Hole Formation in Clumpy Galaxies at High Redshift

, 2008
Massive stellar clumps in high redshift galaxies interact and migrate to the center to form a bulge and exponential disk in
Bruce G. Elmegreen, Debra Meloy Elmegreen, Fan X., Freitag M., Frédéric Bournaud, Kormendy J., Malbon R. K.   +6 more
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Study on the 1-DOF and 2-DOF VIV of Marine Riser

Shiyou jixie, 2016
The deep water equipment mostly has cylindrical structure, so that VIV phenomenon is their study focus.Numerical simulation has been conducted on the 1-DOF and 2-DOF VIV of the marine riser with the mass ratio of 2 and 5 to study the in-line vibration ...
Song Zhenhua, Duan Menglan
doaj  

Stress-Insensitive Resonant Graphene Mass Sensing via Frequency Ratio

Sensors, 2019
Herein, a peripherally clamped stretched square monolayer graphene sheet with a side length of 10 nm was demonstrated as a resonator for atomic-scale mass sensing via molecular dynamics (MD) simulation.
Xing Xiao, Shang-Chun Fan, Cheng Li, Wei-Wei Xing   +3 more
doaj   +1 more source

Effect of Ni/Si Mass Ratio and Thermomechanical Treatment on the Microstructure and Properties of Cu-Ni-Si Alloys

Materials, 2019
The effect of the Ni/Si mass ratio and combined thermomechanical treatment on the microstructure and properties of ternary Cu-Ni-Si alloys is discussed systematically. The Cu-Ni-Si alloy with a Ni/Si mass ratio of 4–5 showed good comprehensive properties.
Jiango Li, Guojie Huang, X. Mi, L. Peng, H. Xie, Y. Kang   +5 more
semanticscholar   +1 more source

A galactic weigh-in: mass models of SINGS galaxies using chemospectrophotometric galactic evolution models

, 2013
The baryonic mass-to-light ratio used to perform the photometry-to-mass conversion has a tremendous influence on the measurement of the baryonic content and distribution, as well as on the determination of the dark halo parameters.
Amram, Philippe, Boissier, Samuel, Carignan, Claude, de Denus-Baillargeon, Marie-Maude, Hernandez, Olivier   +4 more
core   +3 more sources

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Analytical estimation of fundamental periods of coupled systems

Advances in Civil and Architectural Engineering
This study provides an in-depth analytical investigation to accurately estimate the seismic responses of coupled systems while considering primary–secondary system interactions (PSSIs).
Omid Fereidooni, Panam Zarfam, Mohammadreza Mansoori   +2 more
doaj   +1 more source