Results 121 to 130 of about 943,382 (267)

A deep learning model for mass screening of COVID-19. [PDF]

Int J Imaging Syst Technol, 2021
Dhaka VS, Rani G, Oza MG, Sharma T, Misra A.   +4 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Modeling Low Muscle Mass Screening in Hemodialysis Patients.

Nephron, 2023
Senzaki D, Yoshioka N, Nagakawa O, Inayama E, Nakagawa T, Takayama H, Endo T, Nakajima F, Fukui M, Kijima Y, Oyama Y, Kudo R, Toyama T, Yamada Y, Tsurusaki K, Aoyama N, Matsumura T, Yamahara H, Miyasato K, Kitamura T, Ikenoue T.   +20 more
europepmc   +1 more source

Mass screening is a key component to fight against SARS-CoV-2 and return to normalcy. [PDF]

Med Rev (2021), 2022
Feng Z, Zhang Y, Pan Y, Zhang D, Zhang L, Wang Q.   +5 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Mass Screening Strategies for Celiac Disease in Apparently Healthy Children and Adolescents: A Systematic Review. [PDF]

Medicina (Kaunas)
Mpakosi A, Cholevas V, Tsantes AG, Pastrikou A, Fragkiadaki A, Zhgabi S, Mougiou V, Iacovidou N, Sokou R.   +8 more
europepmc   +1 more source

A cost-benefit algorithm for rapid diagnosis of tuberculosis and rifampicin resistance detection during mass screening campaigns. [PDF]

BMC Infect Dis, 2022
Donkeng-Donfack VF, Tchatchueng-Mbougua JB, Abanda NN, Ongboulal SM, Djieugoue YJ, Kamdem Simo Y, Mekemnang Tchoupa M, Bekang Angui F, Kuate Kuate A, Mbassa V, Mvondo Abeng Belinga E, Eyangoh S.   +11 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Mass Screening of Celiac Disease: A Crossing Point Between Secondary and Primary Prevention? [PDF]

Gastroenterology
Stahl MG, Leonard MM, Liu E, Pinto-Sanchez MI, Lack G, Catassi C.   +5 more
europepmc   +1 more source