Results 141 to 150 of about 6,872,930 (361)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A comparative study of the prevalence of abdominal aortic aneurysms in the United Kingdom, Denmark, and Australia

, 2001
Objectives: To compare attendance and prevalence of abdominal aortic aneurysm (AAA) in population based randomised trials of sonographic screening in the United Kingdom, Western Australia, and Denmark.
Jamrozik, K., Buxton, M. J., Fasting, H., Couto, E., Scott, R. A. P., Duffy, S., Juul, S., CASS GrpCouto, E., Colehan, J., Druce, S., Norman, P., Langham-Brown, J., Collin, J., Lindholt, J., Kay, D. N., Coutto, E., Bridgewater, S., Ashton, H., Jamrozik, Konrad, Vardulaki, K., Hardy, E., Henneberg, E. W., Day, N. E., Bryan, Stirling, Walker, N., Dewbury, K., Vammen, S., Sahlholdt, A.   +27 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

True Vertigo Patients in Emergency Department; an Epidemiologic Study

Emergency, 2016
Introduction: Vertigo prevalence is estimated to be 1.8% among young adults and more than 30% in the elderly. 13-38% of the referrals of patients over 65 years old in America are due to vertigo.
Ali Shahrami, Mahdi Norouzi, Hamid Kariman, Hamid Reza Hatamabadi, Ali Arhami Dolatabadi   +4 more
doaj  

Impact of computer-aided detection prompts on the sensitivity and specificity of screening mammography.

, 2005
OBJECTIVES: To determine the value of computer-aided detection (CAD) for breast cancer screening. DESIGN: Two sets of mammograms with known outcomes were used in two studies.
Champness, J, Given-Wilson, R, Johnston, K, J Champness, R Given-Wilson, K Johnston, Potts, H, H Potts, Taylor, P, P Taylor   +9 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Triage strategies in cervical cancer detection in Mexico: methods of the FRIDA Study

Salud Pública de México, 2016
Objective. This paper describes the study design and base- line characteristics of the study population, including the first 30 829 women who enrolled in the Forwarding Research for Improved Detection and Access for Cervical Cancer Screening and Triage ...
Leticia Torres-Ibarra, Eduardo Lazcano-Ponce, Eduardo L Franco, Jack Cuzick, Mauricio Hernández-Ávila, Attila Lorincz, Berenice Rivera, Paula Ramírez, Indira Mendiola-Pastrana, Samantha E Rudolph, Leith León-Maldonad, Rubí Hernández, Elizabeth Barrios, Patti Gravitt, Anna Barbara Moscicki, Kathleen M Schmeler, Yvonne N Flores, Pablo Méndez-Hernández, Jorge Salmerón, FRIDA Study Group*   +19 more
doaj  

Operational Advantages of Novel Strategies Supported by Portability and Artificial Intelligence for Breast Cancer Screening in Low-Resource Rural Areas: Opportunities to Address Health Inequities and Vulnerability

Medicina
Early detection of breast cancer plays a crucial role in reducing the number of cases diagnosed at advanced stages, thereby lowering the high healthcare costs required to achieve disease-free survival and helping to prevent avoidable premature deaths ...
Wolmark Xiques-Molina, Ivan David Lozada-Martinez, Ornella Fiorillo-Moreno, Angel Luis Hernández-Lastra, Valmore Bermúdez   +4 more
doaj   +1 more source

Newborn Mass Screening in Japan

, 1984
http://dx.doi.org/10.1007 ...
Wada, Yoshiro
core