Results 141 to 150 of about 5,393,319 (311)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

A Push for Real Normal: Mass Screening for COVID-19. [PDF]

Clin Chem, 2021
Poon LLM.
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Estimating the long-term effects of mass screening for latent and active tuberculosis in the Marshall Islands. [PDF]

Int J Epidemiol, 2022
Ragonnet R, Williams BM, Largen A, Nasa J, Jack T, Langinlur MK, Ko E, Rahevar K, Islam T, Denholm JT, Marais BJ, Marks GB, McBryde ES, Trauer JM.   +13 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Assessing afebrile malaria and bed-net use in a high-burden region of India: Findings from multiple rounds of mass screening. [PDF]

PLoS One, 2023
Garg S, Gupta V, Patel K, Dewangan M, Nanda P, Sridhar R, Singh G.   +6 more
europepmc   +1 more source

Opinions, practice patterns, and perceived barriers to lung cancer screening among attending and resident primary care physicians

Risk Management and Healthcare Policy, 2018
Louise M Henderson,1 Laura M Jones,1 Mary W Marsh,1 Alison T Brenner,2,3 Adam O Goldstein,4 Thad S Benefield,1 Mikael Anne Greenwood-Hickman,5 Paul L Molina,1 M Patricia Rivera,2 Daniel S Reuland2,3 1Department of Radiology, The University of North ...
Henderson LM, Jones LM, Marsh MW, Brenner AT, Goldstein AO, Benefield TS, Greenwood-Hickman MA, Molina PL, Rivera MP, Reuland DS   +9 more
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Regression model for predicting core body temperature in infrared thermal mass screening. [PDF]

IPEM Transl, 2022
Limpabandhu C, Hooper FSW, Li R, Tse Z.
europepmc   +1 more source