Results 131 to 140 of about 6,872,930 (361)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Viremic blood donor found by a rapid screening method in a season of high human parvovirus B19 activity in Niterói, Rio de Janeiro, Brazil

Memorias do Instituto Oswaldo Cruz, 2004
Erythrovirus B19 infection is usually benign but may have serious consequences in patients with hemolytic anemia (transient aplastic crisis), immunodeficiency (in whom persistent infection can lead to chronic bone marrow failure with anemia), or who are ...
Sérgio Setúbal, Cláudia Alessandra da Silva Cárdias, Solange Artimos de Oliveira, Jussara Pereira do Nascimento   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Cervical cancer screening in low resource settings: Cytology versus HPV triage for VIA positive women

International Journal of Preventive Medicine, 2019
Background: The objective of the study is to comparatively evaluate performance of human papillomavirus (HPV) hybrid capture 2 (HC2) and cytology as triage tests among visual inspection after application of 3–5% acetic acid (VIA) screen positive women ...
Gauravi A Mishra, Sharmila A Pimple, Subhadra D Gupta   +2 more
doaj   +1 more source

Evaluating changes in women's attitudes towards cervical screening following a screening promotion campaign and a free vaccination program. CHERE Working Paper 2009/3 [PDF]

This study examines behavioural changes brought about by two interventions introduced to lower the incidence of cervical cancer in Australia. The first intervention is a media campaign promoting regular screening behaviour to women.
Marion Haas, Denzil Fiebig, Meliyanni Johar, Rosalie Viney   +3 more
core  

Screening for diabetes in optometric practice [PDF]

, 2010
Diabetes is an increasing problem worldwide and is placing increasing strain on the healthcare system. It often goes undiagnosed for many years until complications occur.
HOWSE, JENNIFER,HELEN, Howse, Jennifer Helen, Howse, Jen   +2 more
core  

Automated nano-electrospray mass spectrometry for protein-ligand screening by noncovalent interaction applied to human H-FABP and A-FABP

, 2003
A method for ligand screening by automated nano-electrospray ionization mass spectrometry (nano-ESI/MS) is described. The core of the system consisted of a chip-based platform for automated sample delivery from a 96-well plate and subsequent analysis ...
Edlund, Per Olof,, Sterling, A.,, Edlund, P-O, Åkerud, Tomas, van Pelt, C K, Roeraade, Johan,, Åkerud, T.,, Åkerud, Tomas,, Sterling, A, Van Pelt, C. K.,, Roeraade, J, Benkestock, K, Lund University., Benkestock, Kurt,   +13 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Fully automated screening of veterinary drugs in milk by turbulent flow chromatography and tandem mass spectrometry

, 2010
There is an increasing interest in screening methods for quick and sensitive analysis of various classes of veterinary drugs with limited sample pre-treatment.
Stolker, A.A.M., Martins, C.P.B., Ruud J. B. Peters, Peters, R.J.B., DiBussolo, J.M., Cláudia P. B. Martins, Richard Zuiderent, Joseph M. DiBussolo, Zuiderent, R., Alida A. M. Stolker   +9 more
core   +1 more source

Advantages and Limitations of the Body Mass Index (BMI) to Assess Adult Obesity

International Journal of Environmental Research and Public Health
Obesity reflects excessive fat deposits. At-risk individuals are guided by healthcare professionals to eat fewer calories and exercise more, often using body mass index (BMI; weight/height2) thresholds for screening and to guide progress and prognosis ...
Yilun Wu, Dan Li, Sten H. Vermund
semanticscholar   +1 more source