Results 51 to 60 of about 887,132 (304)
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Measurement of the Elemental Composition of Materials by Electron Mass Spectrum [PDF]
Журнал нано- та електронної фізики, 2016 The work is concerned with a multichannel detector consisting of mass spectrometer that implements the functions of registration, generation of ion-electron avalanche and giving out information about their number in each channel in the form of logical ...
A.V. Kosulya, V.G. Verbitskiy
doaj +1 more source
Transonic divider for gas chromatograph effluents [PDF]
, 1972 Transonic effluent divider system was developed which permits varying mass input of gas chromatographic effluent into mass spectrometer without affecting performance of gas chromatograph.
Wellman, J. B.
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
In-situ mass-spectrometer of magnetized plasmas
Nuclear Materials and Energy, 2017 Modified mass-spectrometer of magnetized plasmas (MSMP-03) was installed on the linear plasma device PSI-2 in support of plasma-material interaction studies.
I.A. Sorokin +5 more
doaj +1 more source
High-resolution mass spectrometry and velocity map imaging for ultrafast electron dynamics in complex biomolecules [PDF]
EPJ Web of Conferences, 2019 We present a design combining a velocity map imaging electron spectrometer with a reflectron mass spectrometer. Since the two spectrometer sides have different intrinsic requirements for the electric field in the central region, a large number of ...
Månsson Erik P. +7 more
doaj +1 more source
Surface analysis of Mercury with a mass-spectrometer [PDF]
, 2002 Introduction: The European Space Agency BepiColombo mission to Mercury will include a lander, the Mercury Surface Element (MSE). Although the final configuration of instruments is still to be decided, we are developing a mass spectrometer suitable for ...
Benz, W. +4 more
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Tellus: Series B, Chemical and Physical Meteorology, 2014 A high precision continuous measurement system has been developed for analysis of the atmospheric O2/N2 and Ar/N2 ratios based on a mass spectrometry method.
Shigeyuki Ishidoya, Shohei Murayama
doaj +1 more source