Results 81 to 90 of about 1,203,401 (307)

Spatial lipidomics reveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson’s disease primate model

npj Parkinson's Disease, 2023
Metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to the neurotoxin MPP+ in the brain causes permanent Parkinson’s disease-like symptoms by destroying dopaminergic neurons in the pars compacta of the substantia nigra in humans and non ...
Ibrahim Kaya, Anna Nilsson, Dominika Luptáková, Yachao He, Theodosia Vallianatou, Patrik Bjärterot, Per Svenningsson, Erwan Bezard, Per E. Andrén   +8 more
doaj   +1 more source

Democratizing Mass Spectrometry [PDF]

BioTechniques, 2016
Mass spectrometry is often seen as a complicated, highly technical technique requiring years of experience to master. Jeffrey Perkel talks to users about the best ways for novices to approach mass spectrometry experiments.
openaire   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Correction: Wu et al. A Novel Truncated DNAzyme Modified Paper Analytical Device for Point-of-Care Test of Copper Ions in Natural Waters. Chemosensors 2022, 10, 72

Chemosensors
The authors make the following corrections to the published paper [...]
Jiayi Wu, Ming Wang, Huanhuan Hong, Jianyuan Lin, Ning Gan, Wenchao Bi   +5 more
doaj   +1 more source

Turnover and replication analysis by isotope labeling (TRAIL) reveals the influence of tissue context on protein and organelle lifetimes

Molecular Systems Biology, 2023
The lifespans of proteins range from minutes to years within mammalian tissues. Protein lifespan is relevant to organismal aging, as long‐lived proteins accrue damage over time.
John Hasper, Kevin Welle, Jennifer Hryhorenko, Sina Ghaemmaghami, Abigail Buchwalter   +4 more
doaj   +1 more source

Traumatic brain injury induces region-specific glutamate metabolism changes as measured by multiple mass spectrometry methods [PDF]

, 2021
James L. Sowers, Mark L. Sowers, Alexander S. Shavkunov, Bridget E. Hawkins, Ping Wu, Douglas S. DeWitt, Donald S. Prough, Kangling Zhang   +7 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Accumulation of Plasma-Derived Lipids in the Lipid Core and Necrotic Core of Human Atheroma: Imaging Mass Spectrometry and Histopathological Analyses [PDF]

, 2021
Kazunori Nakagawa, Mitsuru Tanaka, Tae-Hun Hahm, Huu-Nghi Nguyen, Toshiro Matsui, Yong-Xiang Chen, Yutaka Nakashima   +6 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

MS²PIP: a tool for MS/MS peak intensity prediction [PDF]

, 2013
Motivation: Tandem mass spectrometry provides the means tomatch mass spectrometry signal observations with the chemical entities that generated them. The technology produces signal spectra that contain information about the chemical dissociation pattern ...
Degroeve, Sven, Martens, Lennart
core   +2 more sources