Results 81 to 90 of about 5,492,223 (387)

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Correction: Wu et al. A Novel Truncated DNAzyme Modified Paper Analytical Device for Point-of-Care Test of Copper Ions in Natural Waters. Chemosensors 2022, 10, 72

Chemosensors
The authors make the following corrections to the published paper [...]
Jiayi Wu, Ming Wang, Huanhuan Hong, Jianyuan Lin, Ning Gan, Wenchao Bi   +5 more
doaj   +1 more source

Plasma lipidomic analysis reveals strong similarities between lipid fingerprints in human, hamster and mouse compared to other animal species

Scientific Reports, 2018
Cardiovascular diseases are often associated with impaired lipid metabolism. Animal models are useful for deciphering the physiological mechanisms underlying these pathologies.
Zied Kaabia, Julie Poirier, Michelle Moughaizel, Audrey Aguesse, Stéphanie Billon-Crossouard, Fanta Fall, Manon Durand, Elie Dagher, Michel Krempf, Mikaël Croyal   +9 more
doaj   +1 more source

Mass spectrometry

Environmental Chemical Analysis, 2018
Download the annotations file of all identified pep-tides. Compute empirically the following P A,H2O : the probability of seeing a water loss in an ion fragment when the fragment contains acidic residues.
Somenath Mitra, P. Patnaik, B. Kebbekus
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Spatial lipidomics reveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson’s disease primate model

npj Parkinson's Disease, 2023
Metabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to the neurotoxin MPP+ in the brain causes permanent Parkinson’s disease-like symptoms by destroying dopaminergic neurons in the pars compacta of the substantia nigra in humans and non ...
Ibrahim Kaya, Anna Nilsson, Dominika Luptáková, Yachao He, Theodosia Vallianatou, Patrik Bjärterot, Per Svenningsson, Erwan Bezard, Per E. Andrén   +8 more
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Comparison of γ-ray spectrometry and ICP-MS methods for measuring radioactive heat-producing elements of rocks: a case study on borehole samples from the Sichuan Basin, China [PDF]

, 2017
We compared the consistency of γ-ray spectrometry and inductively coupled plasma mass spectrometry by analyzing measurement results of the radioactive heat-producing elements U, Th, and K from borehole samples.
Hu, Shengbiao, Qiu, Nansheng, Xu, Ming, Zhu, Chuanqing   +3 more
core   +1 more source

Mass Spectrometry of Oligonucleotides

CHIMIA, 2005
Within the past decade mass spectrometry has undoubtedly consolidated its role as a major player in modern bioanalysis. Mass spectrometry of oligonucleotides is an evolving field that has not reached its culmination point yet, as many aspects of oligonucleotide dissociation in gas phase still need to be clarified.
Jan M. Tromp, Selina T. M. Monn, Stefan Schürch   +2 more
openaire   +6 more sources

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source