Results 71 to 80 of about 1,123,387 (315)
Microscope mode secondary ion mass spectrometry imaging with a Timepix detector.
, 2013 In-vacuum active pixel detectors enable high sensitivity, highly parallel time- and space-resolved detection of ions from complex surfaces. For the first time, a Timepix detector assembly was combined with a secondary ion mass spectrometer for microscope
Andras Kiss +10 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
, 2014 The molecular complexity of biopharmaceuticals puts severe demands on the bioanalytical techniques required for their comprehensive structural characterization.
Rosati, Sara +11 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
A streamlined pipeline for multiplexed quantitative site-specific N-glycoproteomics
Nature Communications, 2020 Comprehensive quantitative profiling of intact glycopeptides remains technically challenging. To address this, the authors here develop an integrated quantitative glycoproteomic workflow, including optimized sample preparation, multiplexed quantification
Pan Fang +8 more
doaj +1 more source
, 2017 Native mass spectrometry and mass spectrometry in general, are powerful analytical tools for studying proteins and protein complexes. Native mass spectrometry may provide accurate mass measurements of large macromolecular assemblies enabling the ...
van de Waterbeemd, M.J. +2 more
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Mass spectrometry of polyurethanes
Polymer, 2019 This review covers the applications of mass spectrometry (MS) and its hyphenated techniques to characterize polyurethane (PU) synthetic polymers and their respective hard and soft segments. PUs are commonly composed of hard segments including methylene bisphenyl diisocyanate (MDI) and toluene diisocyanate (TDI), and soft segments including polyester ...
Tiffany M, Crescentini +3 more
openaire +3 more sources
Parsimonious Charge Deconvolution for Native Mass Spectrometry
, 2018 Charge deconvolution infers the mass from mass over charge (m/z) measurements in electrospray ionization mass spectra. When applied over a wide input m/z or broad target mass range, charge-deconvolution algorithms can produce artifacts, such as false ...
Christopher Becker (1298982) +38 more
core +1 more source
Secondary Ion Mass Spectrometry Imaging of Dictyostelium discoideum Aggregation Streams [PDF]
, 2014 High resolution imaging mass spectrometry could become a valuable tool for cell and developmental biology, but both, high spatial and mass spectral resolution are needed to enable this.
Pa��a-Toli��, Ljiljana +35 more
core +1 more source