Results 51 to 60 of about 1,123,387 (315)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Seasonal Variation in Stable Isotope Ratios of Cow Milk in Vilnius Region, Lithuania

Animals, 2019
Various studies have shown that stable isotope analysis has the potential to verify the geographic origin of foods and drinks. However, stable isotope composition is not always constant in the environment and can even change in the same area.
Andrius Garbaras, Raminta Skipitytė, Justina Šapolaitė, Žilvinas Ežerinskis, Vidmantas Remeikis   +4 more
doaj   +1 more source

Expanding the mass range for UVPD-based native top-down mass spectrometry

, 2019
Native top-down mass spectrometry is emerging as a methodology that can be used to structurally investigate protein assemblies. To extend the possibilities of native top-down mass spectrometry to larger and more heterogeneous biomolecular assemblies ...
Fagerlund, Robert D., Scheltema, Richard A., Tetter, Stephan, Greisch, Jean François, Fineran, Peter C., Tamara, Sem, Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics, Maxwell, Howard W.R., Heck, Albert J.R., Hilvert, Donald, Greisch, Jean-Francois, Afd Biomol.Mass Spect. and Proteomics   +12 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Identification of mono- and dihydroxy bile acids in human feces by gas-liquid chromatography and mass spectrometry

Journal of Lipid Research, 1966
The mono- and disubstituted cholanoic acids present in human feces have been investigated. Extracts of feces were fractionated on silicic acid column and individual bile acids were isolated by preparative thin-layer chromatography. The isolated compounds
Peter Eneroth, Bruce Gordon, Ragnar Ryhage, Jan Sjövall   +3 more
doaj   +1 more source

Accelerator mass spectrometry [PDF]

Mass Spectrometry Reviews, 2008
AbstractIn this overview the technique of accelerator mass spectrometry (AMS) and its use are described. AMS is a highly sensitive method of counting atoms. It is used to detect very low concentrations of natural isotopic abundances (typically in the range between 10−12 and 10−16) of both radionuclides and stable nuclides.
Ragnar, Hellborg, Göran, Skog
openaire   +2 more sources

Formation and recognition of G-quadruplex in promoter of c-myb oncogene by electrospray ionization mass spectrometry

, 2011
In this study, electrospray ionization mass spectrometry (ESI-MS) is used to study the formation of G-quadruplex by d(GGAGGAGGAGGA) which locates at the promoter region of c-myb gene.
Yuan, Gu, Cui, Xiaojie
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Organ-resolved lipid mapping in Steatoda nobilis spider model using high-resolution mass spectrometry imaging and Kendrick mass defect analysis

Frontiers in Chemistry
The noble false widow spider (Steatoda nobilis), a rapidly spreading member of the Theridiidae family, has gained attention for its increasing presence near human habitats and its medical significance due to envenomation reports.
Damien Redureau, J. P. Dunbar, J. P. Dunbar, Raphaël La Rocca, Axel De Monts De Savasse, Quentin Bastiaens, Virginie Bertrand, Christopher Kune, Mathieu Tiquet, Johann Far, Edwin De Pauw, Michel M. Dugon, Loïc Quinton   +12 more
doaj   +1 more source

Bile acids of marsupials. 2. Hepatic formation of vulpecholic acid (1 alpha,3 alpha,7 alpha-trihydroxy-5 beta-cholan-24-oic acid) from chenodeoxycholic acid in a marsupial, Trichosurus vulpecula (Lesson).

Journal of Lipid Research, 1991
Free vulpecholic acid (1 alpha,3 alpha,7 alpha-trihydroxy-5 beta-cholan-24-oic) is the major biliary component of the Australian opossum (Trichosurus vulpecula), accompanied only by a few percent of its taurine conjugate.
J St Pyrek, SP Lee, L Thomsen, C Tasman-Jones, B Leydon   +4 more
doaj   +1 more source