Results 41 to 50 of about 1,123,387 (315)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

A diverse proteome is present and enzymatically active in metabolite extracts

Nature Communications
Metabolite extraction is the critical first-step in metabolomics experiments, where it is generally regarded to inactivate and remove proteins. Here, arising from efforts to improve extraction conditions for polar metabolomics, we discover a proteomic ...
Rachel (Rae) J. House, Molly T. Soper-Hopper, Michael P. Vincent, Abigail E. Ellis, Colt D. Capan, Zachary B. Madaj, Emily Wolfrum, Christine N. Isaguirre, Carlos D. Castello, Amy B. Johnson, Martha L. Escobar Galvis, Kelsey S. Williams, Hyoungjoo Lee, Ryan D. Sheldon   +13 more
doaj   +1 more source

A critical evaluation of the current state-of-the-art in quantitative imaging mass spectrometry.

, 2014
Mass spectrometry imaging (MSI) has evolved into a valuable tool across many fields of chemistry, biology, and medicine. However, arguably its greatest disadvantage is the difficulty in acquiring quantitative data regarding the surface concentration of ...
Ellis, Shane R., Heeren, Ron M. A., Heeren, R.M.A., Bruinen, A.L., Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics, Ellis, S.R., Bruinen, Anne L.   +7 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

On the chemistry of 1-pyrroline in solution and in the gas phase

Scientific Reports, 2017
1-Pyrroline has a highly characteristic odor, which is employed by living organisms for chemical signaling and other purposes, but the mechanism whereby this odor is formed remains poorly understood.
Xiaoping Zhang, Konstantin Chingin, Dacai Zhong, Juchao Liang, Yongzhong Ouyang, Huanwen Chen   +5 more
doaj   +1 more source

A MASSive laboratory tour. An interactive mass spectrometry outreach activity for children

, 2013
It is imperative to fascinate young children at an early stage in their education for the analytical sciences. The exposure of the public to mass spectrometry presently increases rapidly through the common media. Outreach activities can take advantage of
Jungmann, JH, Mascini, N.E., Heeren, R.M.A., Afd Scheikunde Algemeen, Smith, D.F., Sub Biomol.Mass Spectrometry & Proteom., Cillero-Pastor, B., Biomolecular Mass Spectrometry and Proteomics, Eijkel, G.B., Kiss, A., Chughtai, S., Duursma, M.C., Klinkert, I., Dep Scheikunde, Chughtai, K   +14 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Tandem Native Mass-Spectrometry on Antibody-Drug Conjugates and Submillion da Antibody-Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector [PDF]

, 2015
Native mass spectrometry is emerging as a powerful tool for the characterization of intact antibodies and antibody-based therapeutics. Here, we demonstrate new possibilities provided by the implementation of a high mass quadrupole mass selector on the ...
Wang, Guanbo, Alexander Makarov (1319898), Heck, Albert J R, Albert J. R. Heck (9680), Andrey Dyachenko (1405822), Ewald T. J. van den Bremer (1583836), Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics, Guanbo Wang (1329408), Sub Biomol.Mass Spect. and Proteomics, Mike Belov (1583833), Dyachenko, Andrey, Makarov, Alexander, Parren, Paul W H I, Paul W. H. I. Parren (215516), Belov, Mike, De Jong, Rob N., Van Den Bremer, Ewald T J, Rob N. de Jong (843705)   +18 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Condition-controlled divergent trifluoroalkylation: a diversity-oriented synthesis strategy for efficient construction of CF3-decorated carbazole libraries

BMC Chemistry
A condition-controlled divergent trifluoroalkylation strategy for carbazole derivatives has been developed via alkylation with trifluoropyruvate. Employing trifluoroacetic acid (TFA) promoter, FeCl3 catalyst, or AgSbF6 catalyst, a wide scope of mono ...
Peng Chen, Jin Yin, You-Hui Tang, Meng-Yuan Li, Yi-Jun Jiang   +4 more
doaj   +1 more source