Results 21 to 30 of about 1,123,387 (315)

Cluster secondary ion mass spectrometry microscope mode mass spectrometry imaging

, 2013
RATIONALE: Microscope mode imaging for secondary ion mass spectrometry is a technique with the promise of simultaneous high spatial resolution and high-speed imaging of biomolecules from complex surfaces.
Jungmann, JH, Kiss, A., Heeren, R.M.A., Afd Scheikunde Algemeen, Smith, D.F., Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics   +6 more
core   +1 more source

Performing native mass spectrometry analysis on therapeutic antibodies

, 2013
Since the introduction of “soft” ionization techniques, the role of mass spectrometry (MS) in the field of structural biology has increasingly expanded.
Heck, A.J.R., Rosati, S, Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics, Thompson, N.J.   +4 more
core   +1 more source

Automated, parallel mass spectrometry imaging and structural identification of lipids [PDF]

, 2018
We report a method that enables automated data-dependent acquisition of lipid tandem mass spectrometry data in parallel with a high-resolution mass spectrometry imaging experiment.
Mark W. Jervelund, Heeren, Ron M. A., Peter Husen, Ejsing, Christer S.; id_orcid, Eijkel, Gert B., Josch K. Pauling, Hermansson, Martin, Jervelund, Mark W., Heeren, Ron M.A., Ron M. A. Heeren, Shane R. Ellis, Martin Hermansson, Martin R. L. Paine, Ellis, Shane R., Christer S. Ejsing, Ejsing, Christer S., Paine, Martin R.L., Husen, Peter, Gert B. Eijkel, Paine, Martin R. L., Pauling, Josch K.   +20 more
core   +1 more source

Absorption mode FTICR mass spectrometry imaging

, 2013
Fourier transform ion cyclotron resonance mass spectrometry offers the highest mass resolving power for molecular imaging experiments. This high mass resolving power ensures that closely spaced peaks at the same nominal mass are resolved for proper image
Konijnenburg, Marco, Heeren, Ron M. A., O’Connor, Peter B., Heeren, R.M.A., Smith, Donald Francis, Kilgour, David P. A., Kilgour, D.P.A., Konijnenburg, M., Smith, D.F., Sub Biomol.Mass Spectrometry & Proteom., O'Connor, P.B., Biomolecular Mass Spectrometry and Proteomics   +11 more
core   +1 more source

Ion Storage Bias and Ion Fragmentation in the Ion Funnel Trap of a Hybrid Ion Mobility Spectrometer/Quadrupole Time-of-Flight Mass Spectrometer

Zhipu Xuebao
In this study, a detailed experimental characterization of the relative ion abundance bias and the ion fragmentation in an ion funnel trap were reported by using both cytochrome C and ubiquitin samples in a tandem ion funnel hybrid ion mobility ...
Zhi-da GUO, Xi-xuan GU, Kai-qun WU, Chen-lu WANG, Jun-hui LI, Jian-cheng YU, Ke-qi TANG   +6 more
doaj   +1 more source

Detection systems for mass spectrometry imaging: a perspective on novel developments with a focus on active pixel detectors

, 2013
Instrumental developments for imaging and individual particle detection for biomolecular mass spectrometry (imaging) and fundamental atomic and molecular physics studies are reviewed. Ion-counting detectors, array detection systems and highmass detectors
Jungmann, JH, Heeren, R.M.A., Afd Scheikunde Algemeen, Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics   +4 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Fast Mass Microscopy: Mass Spectrometry Imaging of a Gigapixel Image in 34 Minutes

, 2022
[Image: see text] Mass spectrometry imaging (MSI) maps the spatial distributions of chemicals on surfaces. MSI requires improvements in throughput and spatial resolution, and often one is compromised for the other. In microprobe-mode MSI, improvements in
Claes, Britt S. R., Heeren, Ron M. A., Claes, Britt S R, Heeren, Ron M A, Körber, Aljoscha, Anthony, Ian G. M., Keelor, Joel D., Ron M. A. Heeren, Keelor, Joel D, Britt S. R. Claes, Joel D. Keelor, Aljoscha Körber, Ian G. M. Anthony, Anthony, Ian G M   +13 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Two-Dimensional Ion Mobility Spectrometry-Tandem Mass Spectrometry for Probing Structural Diversity of Protein

Zhipu Xuebao
A gas phase ion separation field asymmetric waveform ion mobility spectrometry-ion mobility spectrometry-quadrupole time-of-flight mass spectrometry (FAIMS-IMS-QTOF MS) system that integrates a high-sensitivity and high-resolution racetrack field ...
Kai-qun WU, Yong-qi LEI, Chen-lu WANG, Jun-hui LI, Jian-cheng YU, Ke-qi TANG   +5 more
doaj   +1 more source