Results 31 to 40 of about 919,285 (215)

Two-Dimensional Ion Mobility Spectrometry-Tandem Mass Spectrometry for Probing Structural Diversity of Protein

open access: yesZhipu Xuebao
A gas phase ion separation field asymmetric waveform ion mobility spectrometry-ion mobility spectrometry-quadrupole time-of-flight mass spectrometry (FAIMS-IMS-QTOF MS) system that integrates a high-sensitivity and high-resolution racetrack field ...
Kai-qun WU   +5 more
doaj   +1 more source

Development and validation of an LC-MS/MS method for ruxolitinib quantification: advancing personalized therapy in hematologic malignancies

open access: yesJournal of Pharmacy & Pharmaceutical Sciences
BackgroundHematologic malignancies such as leukemia and lymphoma present treatment challenges due to their genetic and molecular heterogeneity. Ruxolitinib, a Janus kinase (JAK) inhibitor, has demonstrated efficacy in managing these cancers.
Na Li   +6 more
doaj   +1 more source

Rapid brain structure and tumour margin detection on whole frozen tissue sections by fast multiphotometric mid-infrared scanning

open access: yesScientific Reports, 2021
Frozen section analysis is a frequently used method for examination of tissue samples, especially for tumour detection. In the majority of cases, the aim is to identify characteristic tissue morphologies or tumour margins. Depending on the type of tissue,
Tim Kümmel   +8 more
doaj   +1 more source

A diverse proteome is present and enzymatically active in metabolite extracts

open access: yesNature Communications
Metabolite extraction is the critical first-step in metabolomics experiments, where it is generally regarded to inactivate and remove proteins. Here, arising from efforts to improve extraction conditions for polar metabolomics, we discover a proteomic ...
Rachel (Rae) J. House   +13 more
doaj   +1 more source

On the chemistry of 1-pyrroline in solution and in the gas phase

open access: yesScientific Reports, 2017
1-Pyrroline has a highly characteristic odor, which is employed by living organisms for chemical signaling and other purposes, but the mechanism whereby this odor is formed remains poorly understood.
Xiaoping Zhang   +5 more
doaj   +1 more source

Interferometric Mass Spectrometry

open access: yesJournal of the American Society for Mass Spectrometry, 2023
Updated to the published version, J. Am. Soc.
openaire   +3 more sources

Condition-controlled divergent trifluoroalkylation: a diversity-oriented synthesis strategy for efficient construction of CF3-decorated carbazole libraries

open access: yesBMC Chemistry
A condition-controlled divergent trifluoroalkylation strategy for carbazole derivatives has been developed via alkylation with trifluoropyruvate. Employing trifluoroacetic acid (TFA) promoter, FeCl3 catalyst, or AgSbF6 catalyst, a wide scope of mono ...
Peng Chen   +4 more
doaj   +1 more source

Imaging mass spectrometry

open access: yesMass Spectrometry Reviews, 2007
AbstractImaging mass spectrometry combines the chemical specificity and parallel detection of mass spectrometry with microscopic imaging capabilities. The ability to simultaneously obtain images from all analytes detected, from atomic to macromolecular ions, allows the analyst to probe the chemical organization of a sample and to correlate this with ...
McDonnell, L.A., Heeren, R.M.A.
openaire   +4 more sources

Seasonal Variation in Stable Isotope Ratios of Cow Milk in Vilnius Region, Lithuania

open access: yesAnimals, 2019
Various studies have shown that stable isotope analysis has the potential to verify the geographic origin of foods and drinks. However, stable isotope composition is not always constant in the environment and can even change in the same area.
Andrius Garbaras   +4 more
doaj   +1 more source

Identification of mono- and dihydroxy bile acids in human feces by gas-liquid chromatography and mass spectrometry

open access: yesJournal of Lipid Research, 1966
The mono- and disubstituted cholanoic acids present in human feces have been investigated. Extracts of feces were fractionated on silicic acid column and individual bile acids were isolated by preparative thin-layer chromatography. The isolated compounds
Peter Eneroth   +3 more
doaj   +1 more source

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