Results 111 to 120 of about 7,052,915 (349)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The critical evaluation of a comprehensive mass spectral library

, 1999
A description of the methods used to build a high quality, comprehensive reference library of electron-ionization mass spectra is presented. Emphasis is placed on the most challenging part of this project-the improvement of quality by expert evaluation ...
V. Zaikin, A. I. Mikaya, Sparkman, OD, Zhu, D, Clifton, C.L, P. Ausloos, S. E. Stein, D. V. Tchekhovskoi, Mikaya, AI, Zhu, Damo, Lias, SG, S. G. Lias, Sparkman, O.D, Tchekhovskoi, D.V, Mikaya, A.I, Lias, S.G, Stein, S.E, Stein, SE, Zaikin, V, C. L. Clifton, Clifton, CL, Ausloos, P, O. D. Sparkman, Tchekhovskoi, DV, Damo Zhu   +24 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The spectrum of static-light baryons in twisted mass lattice QCD

, 2010
We compute the static-light baryon spectrum with Nf = 2 flavors of sea quarks using Wilson twisted mass lattice QCD. As light valence quarks we consider quarks, which have the same mass as the sea quarks with corresponding pion masses in the range ...
Wiese, Christian, Wagner, Marc
core  

Mass spectrum by LC-MS.

, 2018
Mass spectrum by LC-MS.
Kamalakkannan Soundararajan (5328815), Sankarganesh Devaraj (5328830), Ramya Vaideki Ganesan (5328824), Rajagopal Thangavel (5328812), Achiraman Shanmugam (5328827), Rajkumar Ramalingam (1973722), Padmanabhan Parasuraman (5328836), Archunan Govindaraju (5328833), Ramachandran Rajamanickam (5328818), Ponmanickam Ponnirul (5328821)   +9 more
core   +1 more source

Meson mass spectrum

Physics Letters B, 1969
info:eu-repo/semantics ...
Englert, François, Brout, Hyman Robert, Truffin, Claude   +2 more
openaire   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

mass spectrum

, 2014
Citation: 'mass spectrum' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.M03749 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms. Requests for commercial
openaire   +1 more source

Towards Mass Spectrum Analysis with ASP

Theory and Practice of Logic Programming
Abstract We present a new use of Answer Set Programming (ASP) to discover the molecular structure of chemical samples based on the relative abundance of elements and structural fragments, as measured in mass spectrometry. To constrain the exponential search space for this combinatorial problem, we develop canonical representations of ...
Nils Küchenmeister, Alex Ivliev, Markus Krötzsch   +2 more
openaire   +2 more sources

Baryon Mass Spectrum [PDF]

Progress of Theoretical Physics, 1958
The possibility has been pointed out that if the relative parity between nucleons and particles is assumed to be odd, the lowest order self-energies of baryons coming from the charge-independent strong interaction give the observed baryon mass level ordering. Schwinger also suggested such a level splitting in a discussion of the isospace symmetry.
H. Katsumori, K. Shimoura
openaire   +1 more source