Results 81 to 90 of about 2,871,177 (303)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Heat transfer in the vortex zone of a cyclone-bed chamber of furnace unit with fluidized bed

Весці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2019
An experimental investigation of the heat-transfer coefficient to a spherical probe in a cyclone-bed chamber with fluidized bed in the “cold” and “hot” regimes has been carried out.
E. A. Pitsuha, E. K. Buchilko, Yu. S. Teplitskii, D. S. Slizhuk   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Relative Environmental, Economic, and Energy Performance Indicators of Fuel Compositions with Biomass

Applied Sciences, 2020
The present study deals with the experimental research findings for the characteristics of ignition (ignition delay times, minimum ignition temperature) and combustion (maximum combustion temperature, concentration of anthropogenic emission), as well as ...
Dmitrii Glushkov, Galina Nyashina, Valeriy Medvedev, Kseniya Vershinina   +3 more
doaj   +1 more source

A fractional model of magnetohydrodynamics Oldroyd-B fluid with couple stresses, heat and mass transfer: A comparison among Non-Newtonian fluid models [PDF]

, 2023
Muhammad Arif, Poom Kumam, Thidaporn Seangwattana, Panawan Suttiarporn   +3 more
openalex   +1 more source

The Connection Between Low-Mass X-ray Binaries and (Millisecond) Pulsars: A Binary Evolution Perspective

, 2007
I review the evolutionary connection between low-mass X-ray binaries (LMXBs) and pulsars with binary companions (bPSRs) from a stellar binary evolution perspective.
A. Cumming, C. Bassa, Christopher J. Deloye, V. M. Kaspi, Z. Wang   +4 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Mathematical modeling of the electric spark ignition of the coal-water particle fuel under conditions relevant to the internal combustion engines

MATEC Web of Conferences, 2017
The results of the mathematical simulation of the coal-water fuel particle in the conditions of electric-spark discharge have been given.
Syrodoy Samen, Penyazkov Oleg, Assad Mohamad, Gutareva Nadegda   +3 more
doaj   +1 more source

Isothermal Evaporation Rate of Deposited Liquid Aerosols and the SARS-CoV-2 Coronavirus Survival

Aerosol and Air Quality Research, 2020
It is shown that the evaporation rate of a liquid sample with the height is about several millimeters containing the culture of coronavirus affects its survival on a substrate.
Pavel S. Grinchuk, Katya I. Fisenko, Sergey P. Fisenko, Svetlana M. Danilova-Tretiak   +3 more
doaj   +1 more source