Results 81 to 90 of about 2,277,334 (290)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Modeling of Mechanical Interaction of Reinforcement with Matrix Composite

Механика машин, механизмов и материалов, 2009
There is solved the problem on determination influence of contact parameters between composite reinforcement and a matrix on strengthening and stiffness of a supporting structure. It is executed on a finite element modelling basis.
Yu.M. Pleskachevsky , A.O. Shimanovsky , O.I. Yakubovich , G.M. Kuziomkina   +3 more
doaj  

Transport magnetic currents driven by moving kink crystal in chiral helimagnets

, 2008
We show that the bulk transport magnetic current is generated by the moving magnetic kink crystal (chiral soliton lattice) formed in the chiral helimagnet under the static magnetic field applied perpendicular to the helical axis. The current is caused by
A. S. Ovchinnikov, E. I. Rashba, E. T. Whittaker, I. E. Dzyaloshinskii, I. E. Dzyaloshinskii, I. G. Bostrem, Jun-ichiro Kishine, W. Döring, Yu. A. Izyumov   +8 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Impact of Facebook sponsored advertisements on Egyptian youth’s attitudes and purchase intention

Insights into Language, Culture and Communication
This research paper is trying to examine the impact of Facebook sponsored advertisements on Egyptian youths’ attitudes and purchase intentions. It aims at exploring the relationship between Facebook sponsored advertisements’ personalization, perceived ...
Nashwa Mohamed Ayman, Hanan Gunied, Asmaa El-Mously   +2 more
doaj   +1 more source

Static aeroelastic program [PDF]

, 1975
Set of programs computes geometric, mass, aerodynamic, and structural effects on fighter and transport type aircraft at subsonic and supersonic ...
Roskam, J.
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Dynamics of Circular Metal-Polymeric Plates on an Elastic Foundation. Part I. FREE VIBRATIONS

Механика машин, механизмов и материалов, 2008
The axisymmetrical free vibrations of elastic circular three-layer metal-polymeric plate on en elastic foundation are explored. Reaction of foundation was described on the base of Winkler’s model.
Yu.M. Pleskatshevsky, E.I. Starovoitov , D.V. Leonenko   +2 more
doaj  

Role of social media content marketing on brand image: a case study on mobile service providers in Egypt

Insights into Language, Culture and Communication
This research examines the influence of digital content marketing (DCM) on consumers' perception of brand image in the Egyptian telecommunication industry.
Khaled Essam Eltokhy, Hanan Gunied, Eman Essam   +2 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source