Results 91 to 100 of about 2,292,783 (294)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Dynamics of Circular Metal-Polymeric Plates on an Elastic Foundation. Part I. FREE VIBRATIONS
Механика машин, механизмов и материалов, 2008 The axisymmetrical free vibrations of elastic circular three-layer metal-polymeric plate on en elastic foundation are explored. Reaction of foundation was described on the base of Winkler’s model.
Yu.M. Pleskatshevsky +2 more
doaj
Impact of Facebook sponsored advertisements on Egyptian youth’s attitudes and purchase intention
Insights into Language, Culture and CommunicationThis research paper is trying to examine the impact of Facebook sponsored advertisements on Egyptian youths’ attitudes and purchase intentions. It aims at exploring the relationship between Facebook sponsored advertisements’ personalization, perceived ...
Nashwa Mohamed Ayman +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Variational Principle for Mass Transport
Physical Review Letters, 2018 A variation principle for mass transport in solids is derived that recasts transport coefficients as minima of local thermodynamic average quantities. The result is independent of diffusion mechanism, and applies to amorphous and crystalline systems.
openaire +4 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Impact of Liquid-Liquid Hydrodynamic Focusing on the Efficiency of Heterogeneous Microreactors: Numerical Solution [PDF]
Iranian Journal of Chemical EngineeringMost of the reactions that occur in microreactors take place on the surface, so it is important to keep the reactants close to the reactive wall. One effective technique in this field is the single-phase hydrodynamic focusing.
Yaser Kazemi, Abdullah Irankhah
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
On the move: how transport infrastructure shapes commuter choices in Greater Jakarta
Urban, Planning and Transport ResearchThe government has prioritized the development of rail and road-based systems of urban mass public transportation. This study aims to examine the effect of mass transport infrastructures such as electric rail commuter line (KRL) stations and rapid ...
Ifani Furindiani, Eny Sulistyaningrum
doaj +1 more source