Results 81 to 90 of about 225,767 (306)

Numerical simulation of colloidal dispersion filtration: description of critical flux and comparison with experimental results [PDF]

open access: yes, 2005
During filtration via membrane processes, colloids accumulate at the porous surface leading to fouling phenomena. In this study, a rigorous simulation of momentum and mass transfer using CFD modelling has been developed to describe such an accumulation ...
Bacchin   +16 more
core   +4 more sources

A two-layer shallow flow model with two axes of integration, well-balanced discretization and application to submarine avalanches [PDF]

open access: yes, 2020
We propose a two-layer model with two different axes of integration and a well-balanced finite volume method. The purpose is to study submarine avalanches and generated tsunamis by a depth-averaged model with different averaged directions for the fluid ...
Bouchut, François   +4 more
core   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Angular Momentum Transport via Internal Gravity Waves in Evolving Stars [PDF]

open access: yes, 2014
Recent asteroseismic advances have allowed for direct measurements of the internal rotation rates of many sub-giant and red giant stars. Unlike the nearly rigidly rotating Sun, these evolved stars contain radiative cores that spin faster than their ...
Brown, Ben   +3 more
core   +2 more sources

Mass-transport deposits on Mediterranean continental margins

open access: yes, 2007
Extensive mass transport deposits and multiple slide scars testify widespread and recurrent submarine sediment failures occurring during the late Quaternary on the SW-Adriatic and SE-Sicilian margins. These mass movements and their consequences contributed to shape the continental slopes and fill the basins with characteristic signatures ...
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Hydrodynamic Constraints on Ore Formation by Basin‐Scale Fluid Flow at Continental Margins: Modelling Zn Metallogenesis in the Devonian Selwyn Basin

open access: yesGeochemistry, Geophysics, Geosystems, 2021
The clastic‐dominant (CD‐type) deposits that are contained within sedimentary basins are major resources of Zn, Pb and Ag, but their formation by basin‐scale hydrothermal mass and energy transport processes is still poorly understood.
Alejandro Rodríguez   +3 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Interfacial Crystallization within Liquid Marbles

open access: yesCondensed Matter, 2020
We report interfacial crystallization in the droplets of saline solutions placed on superhydrophobic surfaces and liquid marbles filled with the saline. Evaporation of saline droplets deposited on superhydrophobic surface resulted in the formation of cup-
Edward Bormashenko   +3 more
doaj   +1 more source

Deep crustal heating by neutrinos from the surface of accreting neutron stars

open access: yes, 2018
We present a new mechanism for deep crustal heating in accreting neutron stars. Charged pions ($\pi^+$) are produced in nuclear collisions on the neutron star surface during active accretion and upon decay they provide a flux of neutrinos into the ...
Brown, Edward F.   +6 more
core   +1 more source

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