Results 171 to 180 of about 271,644 (300)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Assessing the feasibility of partner-implemented digital payment systems for health workers: stakeholder perspectives from Uganda's yellow fever mass vaccination campaign - a qualitative study. [PDF]

BMJ Glob Health
Ediau M, Ekirapa Kiracho E, Aweko J, Opio C, Ashaba MS, Waiswa P.   +5 more
europepmc   +1 more source

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li, Li Chen, Tao Wang, Haiyang Jiang, Huijuan Wang, Mengyu Li, Guanpeng Xie, Chunhua Xi, Han Yan, Chunhui Lu, Chenchen Li, Hanyu Zhu, Feihu Sun, Lingdi Yin, Jun Yu, Yi Miao   +15 more
wiley   +1 more source

Drive-through SARS-CoV-2 vaccination has disadvantages that should be considered before recommending it as a method of rapid mass vaccination. [PDF]

Indian J Med Res
Finsterer J.
europepmc   +1 more source

HSP90AB1‐Mediated Ubiquitin‐Proteasome Degradation of ITGBL1 Promotes Osteosarcoma Progression by Inhibiting Endoplasmic Reticulum Stress‐Induced Autophagy

Advanced Science, EarlyView.
This study delineates a novel HSP90AB1‐ITGBL1 signaling axis governing osteosarcoma. HSP90AB1 promotes K63‐linked ubiquitination and proteasomal degradation of ITGBL1. Restoring ITGBL1 induces reactive oxygen species‐dependent endoplasmic reticulum stress and pro‐death autophagy, suppressing tumor growth and metastasis.
Zhen Wang, Zixuan Guo, Chengwei Cao, Ziying Wang, Zifu Huang, Xiujuan Zhang, Yushu Zheng, Diankun She, Hao Zhu, Lingfeng Yu, Xuelin Zhao, Dongquan Xiang, Song Liao, Xin He, Xintong Ji, Chengsheng Wu, Cheng‐Xiong Xu, Meng Xu   +17 more
wiley   +1 more source

Characterization of Conserved Evolution in H7N9 Avian Influenza Virus Prior Mass Vaccination. [PDF]

Virulence
He D, Wang X, Wu H, Cai K, Song X, Wang X, Hu J, Hu S, Liu X, Ding C, Peng D, Su S, Gu M, Liu X.   +13 more
europepmc   +1 more source

Developing a Roadmap for Mass Vaccination of COVID-19 in Iran: A Qualitative Study. [PDF]

Disaster Med Public Health Prep, 2022
Seyedin H, Dowlati M, Barzegar M, Bahramzadeh S, Khanizade A, Roshanravan M, Adibi H, Barghi-Shirazi F, Rouhollahi M.   +8 more
europepmc   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Why does COVID-19 continue to spread despite mass vaccination? [PDF]

Front Public Health, 2022
Zhang S, Yang Z, Chen ZL, Yue SJ, Zhang S, Tang YP.   +5 more
europepmc   +1 more source

Legitimating European Food Governance of Avian Influenza: Reflecting on the UK and Dutch Public Debates [PDF]

, 2008
Krom, M.P.M.M., de
core   +1 more source