Results 71 to 80 of about 77,966 (263)

Neoadjuvant chemotherapy induces phenotypic mast cell changes in high grade serous ovarian cancer

Journal of Ovarian Research
Background High grade serous ovarian cancer (HGSOC) is the most lethal gynecologic malignancy in which patients have still yet to respond meaningfully to clinically available immunotherapies. Hence, novel immune targets are urgently needed. Our past work
Julia McAdams, Jasmine Ebott, Corinne Jansen, Chloe Kim, Daniela Maiz, Joyce Ou, Linda C. Hanley, Payton De La Cruz, Nicole E. James   +8 more
doaj   +1 more source

TWEAK/Fn14 Signaling Drives Oxidative Cardiac Injury in Systemic Lupus Erythematosus: Evidence From Patient Biomarker Studies, Lupus Mouse Models, and Cardiomyocyte Assays

Arthritis &Rheumatology, EarlyView.
Objective Cardiac involvement is a major cause of morbidity in systemic lupus erythematosus (SLE). Tumor necrosis factor–like weak inducer of apoptosis (TWEAK) is elevated in SLE, but its contribution to lupus‐associated cardiac injury is unclear. We investigated the role of TWEAK/fibroblast growth factor–inducible 14 (Fn14) signaling in SLE‐related ...
Yale Liu, Zhu Yan, Xueting Peng, Meixuan Li, Juan Wang, Yan Zhang, Xiaoqian Hu, Mingzhu Zhou, Kaixuan Ren, Dan Zhang, Xingyi Guo, Yumin Xia, Huanhuan Huo   +12 more
wiley   +1 more source

Characteristics of mast cell infiltration in lung adenocarcinoma and its impact on prognosis

Discover Oncology
Background The role of mast cells in malignancies remains unclear, and there is no clear correlation between mast cells and tumor microvessels, tumor growth, or lung adenocarcinoma (LUAD) prognosis. This study aims to explore the association between mast
Zijian Qiu, Guanchao Pang, Xia Xu, Jun Lin, Pingli Wang   +4 more
doaj   +1 more source

Honeycomb-like Structured Film Regulates Mediator Release from Non-Tumor Mast Cells

European Journal of Inflammation, 2014
We previously reported a honeycomb-like structured film (HCF) stimulates mast cell proliferation and multinucleated formation. In this study, we examined the role of HCF in regulating the release of mediators from cultured mast cells.
K. Sugimoto, H. Choi, M. Tanaka
doaj   +1 more source

Oncolytic Reovirus in Canine Mast Cell Tumor

PLoS ONE, 2013
The usage of reovirus has reached phase II and III clinical trials in human cancers. However, this is the first study to report the oncolytic effects of reovirus in veterinary oncology, focusing on canine mast cell tumor (MCT), the most common cutaneous tumor in dogs.
Chung Chew Hwang, Saori Umeki, Masahito Kubo, Toshiharu Hayashi, Hiroshi Shimoda, Masami Mochizuki, Ken Maeda, Kenji Baba, Hiroko Hiraoka, Matt Coffey, Masaru Okuda, Takuya Mizuno   +11 more
openaire   +4 more sources

Identifying Systemic Lupus Erythematosus From Serum Proteomic Profiles Using Machine Learning and Genetic Risk Stratification

Arthritis &Rheumatology, EarlyView.
Objective Proteome‐wide risk models for lupus remain underexplored. We developed classification models to identify lupus from serum proteomic profiles. Methods Patients with lupus and individuals with other autoimmune diseases in the UK Biobank were included.
Mehmet Hocaoǧlu, Jishnu Das, Amr H. Sawalha   +2 more
wiley   +1 more source

Pathological Observations of Feline Mast Cell Tumor

The Japanese Journal of Veterinary Science, 1974
Seventeen cases of feline mast cell tumor, being 22% of a total feline tumor cases examined during 10 years, were studied pathologically. Mast cell leukemia was detected in only one out of 5 autopsy cases examined. In 3 cases, multiple skin lesions reported rarely in feline cases, were present involving the epidermis as well as the dermis with ...
GOTO, Naoaki, OZASA, Manabu, TAKAHASHI, Reiji, ISHIDA, Kiichi, FUJIWARA, Kosaku   +4 more
openaire   +3 more sources

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Systemic mastocytosis with terminal leukemic manifestation in two dogs

Brazilian Journal of Veterinary Pathology, 2017
Systemic mastocytosis (SM) with leukemic manifestation is rarely reported in veterinary patients. Here, we describe two cases of systemic mastocytosis with leukemic spread of neoplastic mast cells in adult dogs, including their clinical signs, clinical ...
Roselene Ecco, Anna L. F. V. Assumpção, Rodrigo M. Couto, Rachel L. A. L. T. Neto, Pâmela C. L. G. Valente, Conrado O. Gamba, Fabiola O. P. Leme, Paulo R. O. Paes   +7 more
doaj   +1 more source