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Identification of Mast Cells and Mast Cell Subpopulations
2008Mast cells generate mediators of inflammation which are stored in granules and secreted on activation either by allergen crosslinking of membrane-bound IgE or through other stimuli. Most methods for mast cell identification rely on the histochemical detection of constituents of the secretory granules. Although staining for mast cells with histochemical
Buckley, Mark, Walls, Andrew F.
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Mast Cell Purification Protocols
2014Studying a tissue-specific mast cell can be of particular benefit given the heterogeneity that is known to exist among mast cells isolated or developed from different sources. Methods for isolating mast cells from a variety of tissues have been in existence for a number of years although, over time, these methodologies have been refined.
Jasmine, Farrington +2 more
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Mast Cell–Targeting Therapies in Mast Cell Activation Syndromes
Current Allergy and Asthma ReportsProvide an overview of the expanding landscape of mast cell (MC)-targeting treatments in mast cell activation syndromes (MCAS).Tyrosine-kinase inhibitors (TKIs) targeting wild-type and mutated KIT can efficiently induce MC depletion. Avapritinib and midostaurin can also temper IgE-mediated degranulation.
Sabato, Vito +4 more
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2014
The role of mast cells in allergy remained unrevealed until the observation that they contained histamine in 1953, and then the discovery of immunoglobulin E (IgE) in 1966, nearly a century after Ehrlich's first publication. After the discovery of IgE, myeloma-derived IgE from Peter Shackford, who made a great contribution to mankind by providing 40 ...
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The role of mast cells in allergy remained unrevealed until the observation that they contained histamine in 1953, and then the discovery of immunoglobulin E (IgE) in 1966, nearly a century after Ehrlich's first publication. After the discovery of IgE, myeloma-derived IgE from Peter Shackford, who made a great contribution to mankind by providing 40 ...
openaire +2 more sources
Understanding human mast cells: lesson from therapies for allergic and non-allergic diseases
Nature Reviews Immunology, 2021P V Kolkhir +2 more
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