Results 131 to 140 of about 148,300 (268)

Environmental chemicals and the tumor immune microenvironment

iMeta, EarlyView.
Impact of representative environmental chemicals on tumor immune microenvironment (TIME). Representative environmental chemicals are ubiquitously distributed across air, soil, aquatic systems, and biota. These toxicants enter the human body via multiple exposure routes, including inhalation, dietary intake, and dermal absorption, subsequently ...
Tongtong Zhang, Yanxia Hu, Weiran Zhang, Yang Jin, Chaoyang Sun, Afshin Samali, Shunqing Xu, Xia Sheng   +7 more
wiley   +1 more source

Mast cells promote pathology and susceptibility in tuberculosis. [PDF]

Elife
Gupta A, Taneja V, Rangel-Moreno J, Naqvi N, Abhimanyu, Tao Y, Ahmed M, Chauhan KS, de Leon DT, Ramírez-Martínez G, Jiménez-Alvarez L, Luna-Rivero C, Zuniga J, Kaushal D, Khader SA.   +14 more
europepmc   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Engagement of chymase-positive mast cells in myocardial damage associated with COVID-19. [PDF]

Front Cardiovasc Med
Budnevsky AV, Avdeev SN, Arkhipova ED, Kosanovic D, Shishkina VV, Chernik TA, Ovsyannikov ES, Perveeva IM, Filin AA, Tokmachev RE, Pertsev AV, Ivanova EE, Samoylenko TV, Antakova LN.   +13 more
europepmc   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

AllergoOncology: Emerging Translational and Clinical Significance of Basophils and Mast Cells in Cancer. [PDF]

Clin Transl Allergy
Alder J, Lacy KE, Josephs DH, Spicer J, Bax HJ, Karagiannis SN, Chauhan J.   +6 more
europepmc   +1 more source

FAM107A loss facilitates TTK‐OPTN‐mediated mitophagy to drive docetaxel resistance in castration‐resistant prostate cancer

Interdisciplinary Medicine, EarlyView.
In the progression of docetaxel resistance, downregulation of FAM107A releases its transcriptional repression of TTK, leading to TTK upregulation. TTK enhances the interaction and phosphorylation of OPTN. This activates mitophagy in tumor cells, facilitates clearance of damaged mitochondria, reduces intracellular reactive oxygen species accumulation ...
Yishan Zhang, Fan Zou, Mingdong Wang, Chenyue Wu, Yingwei Xie, Yongjun Quan, Wei Yan, Yupeng Zheng, Lianhua Li, Yuexin Liu, Jian Yu, Hao Ping   +11 more
wiley   +1 more source

The interplay between probiotics and mast cells in gut inflammation: a mini-review. [PDF]

Front Cell Infect Microbiol
Herrera-Saldivar MF, Hernandez-Bautista NC, Quiroga-Garza JM, Vazquez-Guillen JM, Chacon-Salinas R, Rojas-Contreras M, Vazquez-Juarez R, Resendez-Perez D, Tamez-Guerra RS, Rodriguez-Padilla C.   +9 more
europepmc   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Mast Cells and Substance P: Neuroinflammatory Loops at the Molecular and Translational Clinical Levels. [PDF]

Biomolecules
Aitella E, Bruno M, Azzellino G, De Martinis M, Ginaldi L, Romano C.   +5 more
europepmc   +1 more source