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The Mast Cells

1989
Mast cells are normal inhabitants of the connective tissue of most organs. They are characterized by a content of numerous large, electron dense granules which are made up of a proteoglycan matrix showing a metachromatic staining pattern due to its content of strongly sulphated glycosaminoglycans (GAG). The mast cells also contain histamine and are the
L, Enerbäck, K, Norrby
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Mast cell heterogeneity

Canadian Journal of Physiology and Pharmacology, 1984
Increasing evidence for the existence of inter- and intra-species mast cell heterogeneity has expanded the potential biological role of this cell. Early studies suggesting that mast cells at mucosal sites differ morphologically and histochemically from connective tissue mast cells have been confirmed using isolated intestinal mucosal mast cells in the
F, Shanahan   +3 more
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Mast Cell Proteases

2007
Mast cells (MCs) are traditionally thought of as a nuisance for its host, for example, by causing many of the symptoms associated with allergic reactions. In addition, recent research has put focus on MCs for displaying harmful effects during various autoimmune disorders.
Gunnar, Pejler   +3 more
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Is a mast cell a mast cell a mast cell?

Journal of Allergy and Clinical Immunology, 1980
The readers of this JOURNAL are all aware that increases in cyclic adenosine monophosphate (cyclic AMP) in mast cells and basophilic leukocytes in vitro are associated with suppression of the immunologically induced release of mediators. The drugs that are the mainstays of therapy in treating bronchial asthma are, for the most part, capable of ...
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Mast cell leukemia

Blood, 2013
AbstractMast cell leukemia (MCL) is a very rare form of aggressive systemic mastocytosis accounting for < 1% of all mastocytosis. It may appear de novo or secondary to previous mastocytosis and shares more clinicopathologic aspects with systemic mastocytosis than with acute myeloid leukemia. Symptoms of mast cell activation—involvement of the liver,
Sophie, Georgin-Lavialle   +5 more
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Tissue Mast Cells

Nature, 1963
WHILE examining the histology of tuberculoid and lepromatous skin lesions of leprosy, we noted that there were many cells containing acid-fast granules in the cytoplasm, around the granulomatous collections, in the connective tissue and in relation to small capillaries in both types of the disease.
P C, SEN GUPTA, S, GHOSH
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Mast cell stabilisers

European Journal of Pharmacology, 2016
Mast cells play a critical role in type 1 hypersensitivity reactions. Indeed, mast cell mediators are implicated in many different conditions including allergic rhinitis, conjunctivitis, asthma, psoriasis, mastocytosis and the progression of many different cancers.
Tao, Zhang   +3 more
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Mast Cell Disorders

The Journal of Allergy and Clinical Immunology: In Practice, 2016
ivision of Allergy, Immunology and Rheumatology, Department of Pediatrics, Morgan Stanley Children’s Hospital-New York Presbyterian, Columbia University Medical Center, New York, NY astocytosis Center, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass nflicts of ...
Joyce E, Yu, Cem, Akin
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Mast cell biology

Journal of Allergy and Clinical Immunology, 1990
Mast cells are the repository for histamine in the body. They influence the pathophysiology of allergic diseases, such as rhinitis, urticaria, and asthma; regulate bone formation and integrity; help repair and maintain connective tissue; promote wound healing; and probably contribute to the development and preservation of the endothelium and small ...
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Mast Cell Heterogeneity

Trends in Pharmacological Sciences, 1983
Most allergic disorders are now recognized to be complex inflammatory processes involving the participation of a number of different cell types. Of these, the mast cell has assumed a pre-eminent position both because of its ability to release a diversity of spasmogenic, chemotactic and inflammatory mediators, and in view of its strategic location at ...
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