Results 271 to 280 of about 175,673 (317)
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Expert Opinion on Investigational Drugs, 2004
Mast cells play a key role in the induction of allergic disorders, such as asthma and rhinitis, through the release of mediators including histamine, arachidonate products, proteases and several cytokines, which are found in relatively high quantities in these cells.
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Mast cells play a key role in the induction of allergic disorders, such as asthma and rhinitis, through the release of mediators including histamine, arachidonate products, proteases and several cytokines, which are found in relatively high quantities in these cells.
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2005
Apoptosis is a physiological form of cell death. Cells undergoing apoptosis execute a genetically controlled program that leads to organized breakdown of cellular structures and ends in phagocytosis of their remains. In mast cells, several mechanisms regulating apoptosis have been identified including growth factors, tumor necrosis factor-alpha ...
Alexander, Gerbaulet +2 more
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Apoptosis is a physiological form of cell death. Cells undergoing apoptosis execute a genetically controlled program that leads to organized breakdown of cellular structures and ends in phagocytosis of their remains. In mast cells, several mechanisms regulating apoptosis have been identified including growth factors, tumor necrosis factor-alpha ...
Alexander, Gerbaulet +2 more
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Human mast cell proteases and mast cell heterogeneity
Current Opinion in Immunology, 1988Mast cell neutral proteases are distinctive markers of the MC(T) and MC(TC) cells in humans. Measurements of tryptase levels in vivo serve as an overall indicator of mast cell activity. Further research is needed to evaluate the functional role of these proteases as well as each mast cell type in situations related to both health and disease.
J S, Miller, L B, Schwartz
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Journal of the American Medical Association, 1960
During the past few years much information has accumulated concerning the physiological and pathological significance of tissue mast cells. It is more than of historical interest to note that these cells were first clearly described by Ehrlich in 1878.
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During the past few years much information has accumulated concerning the physiological and pathological significance of tissue mast cells. It is more than of historical interest to note that these cells were first clearly described by Ehrlich in 1878.
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Allergy and Asthma Proceedings, 1992
The mast cell, equipped with enzymes, chemotactic factors, a vasoactive amine, an anticoagulant, and lipid-derived proinflammatory products, may be essential in tissue modeling as well as in defense. Its primarily perivascular location in skin and the mucosa of the respiratory tract and the gut assures its availability to counter parasites. By the same
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The mast cell, equipped with enzymes, chemotactic factors, a vasoactive amine, an anticoagulant, and lipid-derived proinflammatory products, may be essential in tissue modeling as well as in defense. Its primarily perivascular location in skin and the mucosa of the respiratory tract and the gut assures its availability to counter parasites. By the same
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Journal of Allergy and Clinical Immunology, 1999
In addition to being a major effector cell in the elicitation of allergic inflammation, mast cells have been found to be activated in various T cell-mediated inflammatory processes and to reside in close physical proximity to T cells. Such observations and the wide spectrum of mediators produced and secreted by mast cells have led investigators to ...
Y A, Mekori, D D, Metcalfe
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In addition to being a major effector cell in the elicitation of allergic inflammation, mast cells have been found to be activated in various T cell-mediated inflammatory processes and to reside in close physical proximity to T cells. Such observations and the wide spectrum of mediators produced and secreted by mast cells have led investigators to ...
Y A, Mekori, D D, Metcalfe
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Mast Cell Pleomorphism: Properties of Intestinal Mast Cells
1987Consistent with their nearly ubiquitous distribution throughout the body, mast cells interact with a variety of cell types and react to numerous environmental stimuli. They can be activated by macrophage (1) and T cell factors (2), by complement fragments, as well as by IgE-allergen interactions.
M, Swieter +4 more
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Otolaryngology–Head and Neck Surgery, 1992
The precise mode of action of the well‐studied cromolyn sodium and the newer nedocromil sodium has not been completely elucidated. Because the drugs do not pass the cell membrane and enter the cell, they are virtually not metabolized, do not exert a systemic action, and therefore are associated with only minimal systemic toxicity.
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The precise mode of action of the well‐studied cromolyn sodium and the newer nedocromil sodium has not been completely elucidated. Because the drugs do not pass the cell membrane and enter the cell, they are virtually not metabolized, do not exert a systemic action, and therefore are associated with only minimal systemic toxicity.
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Identification of Mast Cells and Mast Cell Subpopulations
2008Mast cells generate mediators of inflammation which are stored in granules and secreted on activation either by allergen crosslinking of membrane-bound IgE or through other stimuli. Most methods for mast cell identification rely on the histochemical detection of constituents of the secretory granules. Although staining for mast cells with histochemical
Buckley, Mark, Walls, Andrew F.
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Mast Cell Purification Protocols
2014Studying a tissue-specific mast cell can be of particular benefit given the heterogeneity that is known to exist among mast cells isolated or developed from different sources. Methods for isolating mast cells from a variety of tissues have been in existence for a number of years although, over time, these methodologies have been refined.
Jasmine, Farrington +2 more
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