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Mast Cell–Targeting Therapies in Mast Cell Activation Syndromes
Current Allergy and Asthma ReportsProvide an overview of the expanding landscape of mast cell (MC)-targeting treatments in mast cell activation syndromes (MCAS).Tyrosine-kinase inhibitors (TKIs) targeting wild-type and mutated KIT can efficiently induce MC depletion. Avapritinib and midostaurin can also temper IgE-mediated degranulation.
Sabato, Vito +4 more
openaire +3 more sources
2014
The role of mast cells in allergy remained unrevealed until the observation that they contained histamine in 1953, and then the discovery of immunoglobulin E (IgE) in 1966, nearly a century after Ehrlich's first publication. After the discovery of IgE, myeloma-derived IgE from Peter Shackford, who made a great contribution to mankind by providing 40 ...
openaire +2 more sources
The role of mast cells in allergy remained unrevealed until the observation that they contained histamine in 1953, and then the discovery of immunoglobulin E (IgE) in 1966, nearly a century after Ehrlich's first publication. After the discovery of IgE, myeloma-derived IgE from Peter Shackford, who made a great contribution to mankind by providing 40 ...
openaire +2 more sources
Understanding human mast cells: lesson from therapies for allergic and non-allergic diseases
Nature Reviews Immunology, 2021P V Kolkhir +2 more
exaly
New perspectives on the origins and heterogeneity of mast cells
Nature Reviews Immunology, 2022Ashley St John +2 more
exaly