Results 51 to 60 of about 133,458 (260)

Tick-borne encephalitis (TBE) cases are not random: explaining trend, low- and high-frequency oscillations based on the Austrian TBE time series

BMC Infectious Diseases, 2020
Background Why human tick-borne encephalitis (TBE) cases differ from year to year, in some years more 100%, has not been clarified, yet. The cause of the increasing or decreasing trends is also controversial. Austria is the only country in Europe where a
Franz Rubel, Melanie Walter, Janna R. Vogelgesang, Katharina Brugger   +3 more
doaj   +1 more source

Predictive SOLPS-ITER simulations to study the role of divertor magnetic geometry in detachment control in the MAST-U Super-X configuration

Nuclear Fusion, 2023
The SOLPS-ITER code has been utilised to study the movement of the detachment front location from target towards the X-point for MAST-U Super-X plasmas.
O. Myatra, B. Lipschultz, D. Moulton, K. Verhaegh, B. Dudson, S. Orchard, A. Fil, C. Cowley   +7 more
doaj   +1 more source

Involvement of Hypoxia-Inducible Factor-1 in the Inflammatory Responses of Human LAD2 Mast Cells and Basophils [PDF]

, 2012
We recently showed that hypoxia-inducible factor 1 (HIF-1) plays a crucial role in the pro-allergic functions of human basophils by transcriptional control of energy metabolism via glycolysis as well as directly triggering expression of the angiogenic ...
Claire L Streatfield, Sumbayev, Vadim V., Yasinska, Inna M., Gibbs, Bernhard F., Streatfield, Claire L., Vadim V Sumbayev, Oniku, Abraham E., Bernhard F Gibbs, Streatfield Claire L., Yasinska Inna, Sumbayev Vadim V., Inna Yasinska, Oniku Abraham E., Gibbs Bernhard F., Abraham E Oniku   +14 more
core   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Atypical for northern ungulates, energy metabolism is lowest during summer in female wild boars (Sus scrofa)

Scientific Reports, 2021
Typically, large ungulates show a single seasonal peak of heart rate, a proxy of energy expenditure, in early summer. Different to other large ungulates, wild boar females had peak heart rates early in the year (at ~ April, 1), which likely indicates ...
Thomas Ruf, Sebastian G. Vetter, Johanna Painer, Gabrielle Stalder, Claudia Bieber   +4 more
doaj   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Museu e museologia: interfaces e perspectivas [PDF]

, 2009
112 p.Esta coletânea apresenta algumas das palestras da série MAST COLLOQUIA 2008, as quais refletem diferentes aspectos do tema Museu e Museologia: Interfaces e Perspectivas.Organização de: Marcus Granato, Claudia Penha dos Santos e Maria Lucia de N. M.
Museu de Astronomia e Ciências Afins (MAST)
core  

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Climate-based models for pulsed resources improve predictability of consumer population dynamics: outbreaks of house mice in forest ecosystems. [PDF]

PLoS ONE, 2015
Accurate predictions of the timing and magnitude of consumer responses to episodic seeding events (masts) are important for understanding ecosystem dynamics and for managing outbreaks of invasive species generated by masts. While models relating consumer
E Penelope Holland, Alex James, Wendy A Ruscoe, Roger P Pech, Andrea E Byrom   +4 more
doaj   +1 more source

Seed masting causes fluctuations in optimum litter size and lag load in a seed predator [PDF]

The American Naturalist, 2018
The episodic production of large seed crops by some perennial plants, is referred to as masting and is known to increase seed escape by alternately starving and swamping seed predators. These pulses of resources, however, might also act as an agent of selection on the life histories of seed predators, which could indirectly enhance seed escape by ...
McAdam, Andrew, Boutin, Stan, Dantzer, Ben, Lane, Jeff   +3 more
openaire   +2 more sources