Results 61 to 70 of about 4,769 (235)
Advanced Science, EarlyView.This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao +12 more
wiley +1 more source
Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy
Advanced Science, EarlyView.Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao +2 more
wiley +1 more source
Macroevolutionary consequences of mast seeding - Supplementary Materials
, 2021 Additional 5 figures and 9 tables of supporting analyses.
Dale, Esther E. +4 more
openaire +1 more source
Reproducing reproduction: How to simulate mast seeding in forest models [PDF]
Ecological Modelling, 2018 Masting is the highly variable and synchronous production of seeds by plants. Masting can have cascading effects on plant population dynamics and forest properties such as tree growth, carbon stocks, regeneration, nutrient cycling, or future species composition. However, massing has often been missing from forest models. Those few that simulate masting
G. Vacchiano +12 more
openaire +2 more sources
Advanced Science, EarlyView.Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang +11 more
wiley +1 more source
PLoS ONE, 2019 Mast flowering is synchronised highly variable flowering by a population of perennial plants over a wide geographical area. High seeding years are seen as a threat to native and endangered species due to high predator density caused by the abundance of ...
Samarth +4 more
doaj +1 more source
PLoS ONE, 2013 Seed masting and production of empty seeds have often been considered independently as different strategies to reduce seed predation by animals. Here, we integrate both phenomena within the whole assemblage of seed predators (both pre and post-dispersal) and in two contrasting microsites (open vs.
Perea García-Calvo, Ramón +2 more
openaire +5 more sources
Advanced Science, EarlyView.The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu +4 more
wiley +1 more source
Increasing spring temperatures favor oak seed production in temperate areas
Scientific Reports, 2017 The changes in reproductive phenology (i.e. timing of flowering and fruiting) observed in recent decades demonstrate that tree reproduction has already been altered by climate change.
Thomas Caignard +5 more
doaj +1 more source
Do Female Songbirds Avoid a Mammalian Nest Predator When Selecting Their Nest Site?
Frontiers in Ecology and Evolution, 2020 Perceived predation risk can elicit strong behavioral responses in potential prey. During nest building, songbirds exhibit anti-predator behaviors under experimental conditions.
Alizée Vernouillet +3 more
doaj +1 more source