Results 91 to 100 of about 821,712 (286)

Can we choose evil? A discussion of the problem of radical evil as a modern and ancient problem of freedom [PDF]

, 2004
The problem discussed in this paper emerges from work I’ve\ud done on the modern ideal of autonomy.1 I found that autonomy is often\ud seen as a morally neutral term.
Coeckelbergh, Mark
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A master equation for gravitational perturbations of maximally symmetric black holes in higher dimensions

, 2003
We show that in four or more spacetime dimensions, the Einstein equations for gravitational perturbations of maximally symmetric vacuum black holes can be reduced to a single 2nd-order wave equation in a two-dimensional static spacetime for a gauge ...
Ishibashi, Akihiro, Kodama, Hideo
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Free Will, Self‐Creation, and the Paradox of Moral Luck [PDF]

, 2019
How is the problem of free will related to the problem of moral luck? In this essay, I answer that question and outline a new solution to the paradox of moral luck, the source-paradox solution.
Mickelson, Kristin M.
core  

QuTiP: An open-source Python framework for the dynamics of open quantum systems

, 2011
We present an object-oriented open-source framework for solving the dynamics of open quantum systems written in Python. Arbitrary Hamiltonians, including time-dependent systems, may be built up from operators and states defined by a quantum object class,
Armour, Ashhab, Behnel, Blatt, Blencowe, Breuer, Buluta, Buluta, Cao, Casanova, Dalibard, Dum, Feynman, Forn-Díaz, Franco Nori, Gardiner, Gleyzes, Guerlin, Haroche, Horvath, Hunter, J.R. Johansson, Jones, Klöckner, Lindblad, Mollow, Mølmer, Nataf, Nation, Nation, Nielsen, Oliphant, OʼBrien, OʼConnell, P.D. Nation, Plenio, Schack, Schoelkopf, Schuch, Shevchenko, Steffen, Tan, Tavis, Teufel, Vamivakas, van Rossum, Vukics, Walls, Walls, You, You   +50 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Consolation et psychologie dans la Consolation à Polybe de Sénèque [PDF]

, 2013
Seneca’s Consolation to Polybius illustrate how the philosophical argument cannot be set apart from a twin rhetorical constraint, not only that of the consolation proper, but also that of Seneca’s plea to the addressee for his own recall: hence the ...
Prost, François
core  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source