Results 111 to 120 of about 1,966,371 (280)
Concern vs control: a public servant’s guide to impact
Policy Design and PracticePublic servants operate in a complex working environment, navigating 40 distinct factors while striving to create public value through their policy practices.
Mitzi Bolton
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Sellars's Master Argument for Conceptualism
European Journal of PhilosophyAbstract This paper reconstructs what I call Sellars's ‘master argument’ for conceptualism regarding Kantian intuitions—a coherent argumentative thread that appears throughout his works beginning with Science and Metaphysics .
openaire +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Species, ideas and idealism: The scholastic and Cartesian background of Berkeley's master argument
, 2001 This dissertation situates Berkeley's "master argument" for idealism (PHK I, 23 and DHP I, 200) in the context of Descartes' theory of ideas, and seeks to show that within that context the argument is convincing. In addition, the dissertation argues that
Clemenson, David Lee
core
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
ENGLISH-THE UPSHOTS AND SOCIO-CULTURAL CHARACTER FOR MUSLIM WOMEN IN ISLAMIC SOCIETY
دی اسکالر, 2020 Social advances and legal-based socio-cultural scholars have argued that “character legislative issues” weaken social advances and undermine their effectiveness in an open approach.
Rizwana Jabeen +2 more
doaj
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source