Results 101 to 110 of about 821,712 (286)
The translational turn in narrative medicine: A study of Margherita Guidacci’s Neurosuite
Encounters in TranslationThis essay invokes a translational turn in narrative medicine. My argument is grounded in two primary considerations: first, that illness is a fundamentally estranging experience resembling that of speaking a foreign language, and second, that ...
Marta Arnaldi
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What Would Humboldt Say: A Case of General Bildung in Vocational Education?
International Journal for Research in Vocational Education and Training, 2016 A classic philosopher in the Bildung tradition, Humboldt argued that general Bildung was the opposite of specialist training (vocational education). This has been a matter of contention and the aim here is to revisit the issue through an empirical case ...
Ruhi Tyson
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The Advocate: Should He Speak or Write? [PDF]
, 1992 This speech was given by The Rt. Hon. Lord Mackay on April 3, 1991, at Fordham University\u27s School of Law as the John F.
Mackay, The Rt. Hon. Lord
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
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Conceptual Space for Illiberal Democracy
Politics and GovernanceFor over a decade, populists have been experimenting with a new political regime–illiberal democracy. Vocal proponents, such as Hungary’s PM Viktor Orbán, develop “democratic illiberalism” as an ideational model for the illiberal‐democratic regime they ...
Ruzha Smilova
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Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Facts, skills and intuition : A typology of personal knowledge [PDF]
, 2011 This paper introduces a knowledge model in which the types of knowledge are formed according to the nature of knowledge. First we use Ryle’s distinction of “that” and “how” knowledge, to which we add further three types. The five knowledge types are then
Ackermann, Fran +3 more
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Sellars's Master Argument for Conceptualism
European Journal of PhilosophyAbstract This paper reconstructs what I call Sellars's ‘master argument’ for conceptualism regarding Kantian intuitions—a coherent argumentative thread that appears throughout his works beginning with Science and Metaphysics .
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