Results 101 to 110 of about 1,966,371 (280)

THE WORST ARGUMENT IN THE WORLD – DEFENDED

open access: yes, 2017
In this article, I argue that Berkeley's master argument is not the worst argument in the world – more like third or fourth.
Scott Stapleford
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Bad News for Moral Error Theorists: There Is No Master Argument Against Companions in Guilt Strategies

open access: yes, 2017
A ‘companions in guilt’ (CG) strategy against moral error theory aims to show that the latter proves too much: if sound, it supports an implausible error-theoretic conclusion in other areas such as epistemic or practical reasoning.
Ramon Das (8509131)
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Study in Arthur's thesis about Marx's Being influenced by Hegel's Master-Servant in Labor

open access: yesJournal of Philosophical Investigations, 2014
o one is denying that Hegel had a strong influence on Marx, especially influenced by the Master-Servitude of Phenomenology of Spirit. For people like Arthur, however, it is not more than a Myth.
Mojtaba Seifi , Mohammad Meshkat
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Flavio Baroncelli: A Personal Recollection

open access: yesNordicum-Mediterraneum, 2008
Flavio Baroncelli was a formidable philosopher, albeit an unusual—and even "disquieting"—one. His work is well known in Italy, but little known in other countries.
Mikael M. Karlsson
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

On Philosophers' Hallucinations: Naïve Realism and the Master Argument from Hallucination [PDF]

open access: yes
It is widely acknowledged that the Master Argument from Hallucination poses a significant challenge to Naïve Realism, i.e., the view that the phenomenal character of (at least) veridical conscious perceptions is constituted by the obtaining of a relation
Mazzullo, Giorgio
core  

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