Results 101 to 110 of about 2,428,488 (282)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Freedman’s Inequality for Matrix Martingales [PDF]
, 2011 Freedman's inequality is a martingale counterpart to Bernstein's inequality. This result shows that the large-deviation behavior of a martingale is controlled by the predictable quadratic variation and a uniform upper bound for the martingale difference ...
Tropp, Joel A.
core +1 more source
The geometry of variations in Batalin-Vilkovisky formalism
, 2013 This is a paper about geometry of (iterated) variations. We explain why no sources of divergence are built into the Batalin-Vilkovisky (BV) Laplacian, whence there is no need to postulate any ad hoc conventions such as "$\delta(0)=0$" and "$\log\delta(0)=
Kiselev, Arthemy V.
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
The translational turn in narrative medicine: A study of Margherita Guidacci’s Neurosuite
Encounters in TranslationThis essay invokes a translational turn in narrative medicine. My argument is grounded in two primary considerations: first, that illness is a fundamentally estranging experience resembling that of speaking a foreign language, and second, that ...
Marta Arnaldi
doaj +1 more source
What Would Humboldt Say: A Case of General Bildung in Vocational Education?
International Journal for Research in Vocational Education and Training, 2016 A classic philosopher in the Bildung tradition, Humboldt argued that general Bildung was the opposite of specialist training (vocational education). This has been a matter of contention and the aim here is to revisit the issue through an empirical case ...
Ruhi Tyson
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source