Results 21 to 30 of about 439,714 (267)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Complementary Core Competencies for Master of Science in Epidemiology Students [PDF]

open access: yesResearch and Development in Medical Education, 2016
Introduction: Competency-based education has been recommended in training and education of public health to reduce the gap between traditional teaching and the competencies required in practice.
Nayyereh Aminisani   +7 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Programa de Pós-Graduação em Geologia - Dissertações Defendidas 1999 - Mestrado - Instituto de Geociências - Universidade Federal do Rio de Janeiro [PDF]

open access: yesAnuário do Instituto de Geociências, 1999
105 Anuário do Instituto de Geociências - UFRJ Volume 22 / 1999 Nome: Luiz Carlos Rodrigues de Almeida Orientador: Eurípedes Do Amaral Vargas Jr.
doaj  

Master of science

open access: yes
Microplasticretention on beech leaves (Fagus sylvatica) - a case study in Collelongo, Abruzzo, Italy Mohr, J., Klein, M., Brecht, T., Stöwer, S.-C. & E.K. Fischer Microplastic Research at CEN (MRC), Center for Earth System Research and Sustainability, University of Hamburg In this study, the environmental behavior of microplastics on beech leaves ...
Mohr, Jonas   +4 more
openaire   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Programa de Pós-Graduação em Geografia - Dissertações Defendidas 1999 - Mestrado - Instituto de Geociências - Universidade Federal do Rio de Janeiro [PDF]

open access: yesAnuário do Instituto de Geociências, 1999
120 Anuário do Instituto de Geociências - UFRJ Volume 22 / 1999 Programa de Pós-Graduação em Geografia Dissertações Defendidas - Mestrado Nome: Adorea Rebello Da Cunha Albuquerque Orientador: Antonio José Teixeira Guerra Título: Impactos Ambientais
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Programa de Pós-Graduação em Geologia - Dissertações Defendidas 2001 - Mestrado - Instituto de Geociências - Universidade Federal do Rio de Janeiro [PDF]

open access: yesAnuário do Instituto de Geociências, 2001
40 Anuário do Instituto de Geociências - UFRJ Volume 24 / 2001 Programa de Pós-Graduação em Geologia Dissertações Defendidas - Mestrado Nome: Aline Theophilo Silva Orientadores: Claudio Limeira Mello, Cláudio Coelho de Lima e Hélio Maurício Ribeiro
doaj  

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