We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Complementary Core Competencies for Master of Science in Epidemiology Students [PDF]
Introduction: Competency-based education has been recommended in training and education of public health to reduce the gap between traditional teaching and the competencies required in practice.
Nayyereh Aminisani +7 more
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In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Programa de Pós-Graduação em Geologia - Dissertações Defendidas 1999 - Mestrado - Instituto de Geociências - Universidade Federal do Rio de Janeiro [PDF]
105 Anuário do Instituto de Geociências - UFRJ Volume 22 / 1999 Nome: Luiz Carlos Rodrigues de Almeida Orientador: Eurípedes Do Amaral Vargas Jr.
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Microplasticretention on beech leaves (Fagus sylvatica) - a case study in Collelongo, Abruzzo, Italy Mohr, J., Klein, M., Brecht, T., Stöwer, S.-C. & E.K. Fischer Microplastic Research at CEN (MRC), Center for Earth System Research and Sustainability, University of Hamburg In this study, the environmental behavior of microplastics on beech leaves ...
Mohr, Jonas +4 more
openaire +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Programa de Pós-Graduação em Geografia - Dissertações Defendidas 1999 - Mestrado - Instituto de Geociências - Universidade Federal do Rio de Janeiro [PDF]
120 Anuário do Instituto de Geociências - UFRJ Volume 22 / 1999 Programa de Pós-Graduação em Geografia Dissertações Defendidas - Mestrado Nome: Adorea Rebello Da Cunha Albuquerque Orientador: Antonio José Teixeira Guerra Título: Impactos Ambientais
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Programa de Pós-Graduação em Geologia - Dissertações Defendidas 2001 - Mestrado - Instituto de Geociências - Universidade Federal do Rio de Janeiro [PDF]
40 Anuário do Instituto de Geociências - UFRJ Volume 24 / 2001 Programa de Pós-Graduação em Geologia Dissertações Defendidas - Mestrado Nome: Aline Theophilo Silva Orientadores: Claudio Limeira Mello, Cláudio Coelho de Lima e Hélio Maurício Ribeiro
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