Results 51 to 60 of about 474,954 (240)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Maintenance of Stimuli Equivalence Classes: A Study with Students of Fundamental School

open access: yesPsicologia, 2009
The maintenance of equivalence classes is affected by many experimental variables. The present study aimed to investigate the effect of classes size on the formation and maintenance of the equivalence relations with students of the fundamental school (9 ...
Leila Cristina Ferreira Omote   +3 more
doaj  

MATCHING‐TO‐SAMPLE ACCURACY ON FIXED‐RATIO SCHEDULES [PDF]

open access: yesJournal of the Experimental Analysis of Behavior, 1979
Pigeons performing on a matching‐to‐sample procedure were exposed to six fixed‐ratio (FR) schedules (FR 1, 5, 10, 20, 40, and 60) of food reinforcement for correct matching responses. During both a correction and a noncorrection procedure without an intertrial interval (ITI), matching accuracy was lower on FR 1 and FR 60 than at intermediate ratios ...
openaire   +2 more sources

REINFORCER EFFICACY IN A DELAYED MATCHING‐TO‐SAMPLE TASK [PDF]

open access: yesJournal of the Experimental Analysis of Behavior, 1998
Five domestic hens were exposed to a delayed matching‐to‐sample task. Conditions 1, 5, and 8 were variable‐delay conditions in which five delays (0.25, 1, 2, 4, and 8 s) from the red or green sample to the presentation of the red and green comparison stimuli were presented a number of times during each session. In the fixed‐delay condition (Condition 3)
R, Weavers, T M, Foster, W, Temple
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

RECOMBINATIVE GENERALIZATION OF SUBWORD UNITS USING MATCHING TO SAMPLE [PDF]

open access: yesJournal of Applied Behavior Analysis, 2010
The purpose of the current study was to develop and test a computerized matching‐to‐sample (MTS) protocol to facilitate recombinative generalization of subword units (onsets and rimes) and recognition of novel onset—rime and onset—rime—rime words. In addition, we sought to isolate the key training components necessary for recombinative generalization ...
Mahon, Catherine   +2 more
openaire   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Same/different concept learning by capuchin monkeys in matching-to-sample tasks.

open access: yesPLoS ONE, 2011
The ability to understand similarities and analogies is a fundamental aspect of human advanced cognition. Although subject of considerable research in comparative cognition, the extent to which nonhuman species are capable of analogical reasoning is ...
Valentina Truppa   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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