Results 61 to 70 of about 474,954 (240)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

EFECTO DE DOS TIPOS DE DESCRIPCIONES PRECONTACTO SOBRE LA EJECUCIÓN INSTRUMENTAL Y DESCRIPCIONES POSCONTACTO EN TAREAS DE IGUALACIÓN DE LA MUESTRA [PDF]

Acta Colombiana de Psicología, 2010
The effects of different kinds of pre-contact descriptions were assessed: a) one specific and pertinent (EP) in the situation components of the stimulus (SE), Response (R), and Consequences (C); and b) one that shows variations about the correct and ...
Ortiz, Gerardo, González, Víctor
doaj  

Response latencies in human matching-to-sample [PDF]

Perception & Psychophysics, 1970
Optimum characterization of individual information-processing skills requires isolation of assessable components. In matching-to-sample, three elementary processes might be separated if a proposed model of serial, selfterminating search were supported: registration of the stimulus in short-term memory, comparison of the two registered stimuli, and ...
openaire   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Creative behavior: Effects of the verbal consequences type

Revista Argentina de Ciencias del Comportamiento, 2014
The effects of different types of verbal consequences were evaluated in second order conditional discrimination tasks on creative behavior emergence in four experimental groups.
Carpio, Claudio, Pacheco, Virginia, Morales, Germán, Carranza, Jamillet, Pacheco-Lechón, Linda, Narayanam-Rodríguez Medina, Raul   +5 more
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Effects of stimuli organization on identity matching-to-sample performances of persons with autism / Desempenho de pessoas com autismo em tarefas de emparelhamento com o modelo por identidade: efeitos da organização dos estímulos

Psicologia: Reflexão e Crítica, 2008
This study assessed the performance of 20 persons with autism in an identity matching-to-sample task, using two procedures with different stimuli arrangements and different response requirements.
Camila Graciella Santos Gomes, Deisy das Graças de Souza   +1 more
doaj  

Distraction of symbolic behavior in regular classrooms

Frontiers in Psychology, 2012
The purpose of the present study is to develop more precise methods to explore the interaction between contextual factors in teacher instructions in regular classroom settings and students’ abilities to use symbolic information in the instruction.
Stefan eBillinger
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source