Results 131 to 140 of about 1,198,098 (316)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Stability in matching markets: literary review from static matching to dynamic matching [PDF]
reservedThis elaborate aims to collect and review the young but quite large literature on dynamic matching, which originates from the one developed in the 60s on (static) matching markets, which in turn led two of its main contributors, the mathematician
BORRA, NUNZIO
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Agreement toward stability in senior matching markets [PDF]
A stable matching disrupted by the retirement of workers or the opening, by firms, of positions is said to be firm quasi stable. We prove that, when firms have responsive preferences, the set of stable matchings unanimously preferred by workers to a ...
David Cantala
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Propensity score matching [PDF]
The typical evaluation problem aims at quantifying the impact of a ÔtreatmentÕ (e.g. a training programme, a reform, or a medicine) on an outcome of interest (such as earnings, school attendance or illness indicators), where a group of units, the ...
Barbara Sianesi
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Sequential Matching Estimation of Dynamic Causal Models [PDF]
This paper proposes sequential matching and inverse selection probability weighting to estimate dynamic casual effects. The sequential matching estimators extend simple, matching estimators based on propensity scores for static causal analysis that have ...
Michael Lechner
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Stability and Nash implementation in matching markets with couples [PDF]
We consider two-sided matching markets with couples. First, we extend a result by Klaus and Klijn (2005, Theorem 3.3) and show that for any weakly responsive couples market there always exists a "double stable" matching, i.e., a matching that is stable ...
Claus-Jochen Haake, Bettina Klaus
core +3 more sources