Results 61 to 70 of about 389,994 (266)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
History Matching Reservoir Models With Many Objective Bayesian Optimization
Applied AI LettersReservoir models for predicting subsurface fluid and rock behaviors can now include upwards of billions (and potentially trillions) of grid cells and are pushing the limits of computational resources.
Steven Samoil +3 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Estimation of Variance Components in Linear Mixed Models with Commutative Orthogonal Block Structure
Revista Colombiana de Estadística, 2013 Segregation and matching are techniques to estimate variance components in mixed models. A question arising is whether segregation can be applied in situations where matching does not apply.
SANDRA S. FERREIRA +3 more
doaj
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
User preferences in ride-sharing mathematical models for enhanced matching
Scientific ReportsRide-sharing services have attracted significant interest due to overcrowding, limited energy resources, and environmental concerns. This study proposes a mathematical programming model that integrates user preferences into the ride-sharing problem with ...
Zahra Dastani +3 more
doaj +1 more source
Epidemiological and evolutionary outcomes in gene-for-gene and matching allele models
Frontiers in Plant Science, 2016 Gene-for-gene (GFG) and matching-allele (MA) models are qualitatively different paradigms for describing the outcome of genetic interactions between hosts and pathogens.
Peter Holmes Thrall +3 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Match-Unity: Long-Form Text Matching With Knowledge Complementarity
IEEE AccessSemantic text matching is a fundamental task in Natural Language Processing, with existing methods mainly focusing on short texts. However, handling long texts remains a challenge, as conventional approaches often involve slicing or keyword filtering ...
Zhiyi He +6 more
doaj +1 more source