Results 81 to 90 of about 7,531,042 (311)

Matching patients to clinical trials with large language models

Nature Communications
Patient recruitment is challenging for clinical trials. We introduce TrialGPT, an end-to-end framework for zero-shot patient-to-trial matching with large language models.
Qiao Jin, Zifeng Wang, Charalampos S. Floudas, Fangyuan Chen, Changlin Gong, Dara Bracken-Clarke, Elisabetta Xue, Yifan Yang, Jimeng Sun, Zhiyong Lu   +9 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

"Real Indeterminacy of Stationary Equilibria in Matching Models with Media of Exchange" [PDF]

In this paper, it is shown that real indeterminacy of stationary equilibria generically arises in most matching models with perfectly divisible media of exchange.
Takashi Shimizu, Kazuya Kamiya
core  

Bayesian non-linear matching of pairwise microarray gene expressions [PDF]

, 2008
In this paper, we present a Bayesian non-linear model to analyze matching pairs of microarray expression data. This model generalizes, in terms of neural networks, standard linear matching models. As a practical application, we analyze data of patients
Marín Díazaraque, Juan Miguel, Nieto, Carmen   +1 more
core   +1 more source

User preferences in ride-sharing mathematical models for enhanced matching

Scientific Reports
Ride-sharing services have attracted significant interest due to overcrowding, limited energy resources, and environmental concerns. This study proposes a mathematical programming model that integrates user preferences into the ride-sharing problem with ...
Zahra Dastani, Hamidreza Koosha, Hossein Karimi, Abolfazl Mohammadzadeh Moghaddam   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Accounting For Endogenous Search Behavior in Matching Function Estimation [PDF]

We show that equilibrium matching models imply that standard estimates of the matching function elasticities are exposed to an endogeneity bias, which arises from the search behavior of agents on either side of the market.
Jolivet, Grégory, Borowczyk Martins, Daniel, Postel-Vinay, Fabien   +2 more
core  

Generative Lines Matching Models

CoRR
In this paper we identify the source of a singularity in the training loss of key denoising models, that causes the denoiser's predictions to collapse towards the mean of the source or target distributions. This degeneracy creates false basins of attraction, distorting the denoising trajectories and ultimately increasing the number of steps required to
Ori Matityahu, Raanan Fattal
openaire   +3 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source