Results 91 to 100 of about 26,173,429 (328)
IFAC Proceedings Volumes, 1990 Abstract The linear continuous basic time-invariant control system consisting of a generator of a command variable, of an ideal model response and of the control process is fitted up by three controllers: one in the feedback and two in the feedforward.
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A new CNN deep learning model for computer-intelligent color matching
Nonlinear EngineeringTo accurately color the clothing of textile enterprises, many scholars have proposed intelligent color-matching models. However, these intelligent color-matching models still have problems with incomplete color-matching functions and low color-matching ...
He Zhibin, Tan Yanmei, Li Sa
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Animal models of vitiligo: Matching the model to the question
Dermatologica Sinica, 2014 Vitiligo is an autoimmune disease of the skin that is characterized by patchy depigmentation (i.e., white spots) and results from the loss of melanocytes, which are pigment-producing cells.
Kingsley I. Essien, John E. Harris
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
History Matching Reservoir Models With Many Objective Bayesian Optimization
Applied AI LettersReservoir models for predicting subsurface fluid and rock behaviors can now include upwards of billions (and potentially trillions) of grid cells and are pushing the limits of computational resources.
Steven Samoil +3 more
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Estimation of Variance Components in Linear Mixed Models with Commutative Orthogonal Block Structure
Revista Colombiana de Estadística, 2013 Segregation and matching are techniques to estimate variance components in mixed models. A question arising is whether segregation can be applied in situations where matching does not apply.
SANDRA S. FERREIRA +3 more
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