Results 101 to 110 of about 458,841 (313)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Does Bargaining Matter in the Small Firm Matching Model? [PDF]
In this article, we use a stylized model of the labor market to investigate the effects of three alternative and well-known bargaining solutions. We apply the Nash, the Egalitarian and the Kalai-Smorodinsky bargaining solutions in the small firm’s ...
Malherbet, Franck +2 more
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Matching across space: evidence from Finland [PDF]
This paper studies spatial aspects in local labour markets in Finland from the perspective of a matching approach. The monthly data comprise 173 Local Labour Office are as over a 12-year period between January 1991 and August 2002.
Sanna-Mari Ahtonen
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Matched bipartite block model with covariates
J. Mach. Learn. Res., 2017 Community detection or clustering is a fundamental task in the analysis of network data. Many real networks have a bipartite structure which makes community detection challenging. In this paper, we consider a model which allows for matched communities in the bipartite setting, in addition to node covariates with information about the matching.
Zahra S. Razaee +2 more
openaire +5 more sources
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Matching in thin labour markets: panel data evidence from Finland, 1991-2002 [PDF]
The matching function that postulates a relationship between the flow of new matches and stock of job seekers and vacancies has attracted considerable attention, both theoretical and empirical during the last decade.
Jaakko Pehkonen +2 more
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Bayesian non-linear matching of pairwise microarray gene expressions [PDF]
, 2008 In this paper, we present a Bayesian non-linear model to analyze matching pairs of microarray expression data. This model generalizes, in terms of neural networks, standard linear matching models. As a practical application, we analyze data of patients
Marín Díazaraque, Juan Miguel +2 more
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Marker-free Automatic Matching of Range Data
, 2005 Matching of multiple views is often addressed in 3D-model generation and is normally a two-stage process consisting of a coarse and a fine matching stage.
Liu, Rui +3 more
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