Results 91 to 100 of about 2,935,085 (336)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Coalmine image matching by fusing multi-level feature enhancement and weighted grid statistics
Meitan kexue jishuImage feature extraction and matching is a critical technique for video and image stitching, visual localization and navigation in underground coal mines.
Heping LI +5 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Asymptotic normality for $m$-dependent and constrained $U$-statistics, with applications to pattern matching in random strings and permutations [PDF]
, 2021 Svante Janson
openalex +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Indoor Place Categorization based on Adaptive Partitioning of Texture Histograms
ScienceOpen Research, 2014 How can we localize ourselves within a building solely using visual information, i.e. when no data about prior location or movement are available? Here, we define place categorization as a set of three distinct image classification tasks for view ...
Sven Eberhardt
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
An Algorithm to Compute the Character Access Count Distribution for Pattern Matching Algorithms
Algorithms, 2011 We propose a framework for the exact probabilistic analysis of window-based pattern matching algorithms, such as Boyer–Moore, Horspool, Backward DAWG Matching, Backward Oracle Matching, and more.
Sven Rahmann, Tobias Marschall
doaj +1 more source
Non Gaussian extrema counts for CMB maps
, 2011 In the context of the geometrical analysis of weakly non Gaussian CMB maps, the 2D differential extrema counts as functions of the excursion set threshold is derived from the full moments expansion of the joint probability distribution of an isotropic ...
A. G. Doroshkevich +6 more
core +2 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source