Results 91 to 100 of about 977,784 (305)

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Brain-Like Navigation Scheme based on MEMS-INS and Place Recognition

Applied Sciences, 2019
Animals have certain cognitive competence about the environment so they can correct their navigation errors. Inspired by the excellent navigational behavior of animals, this paper proposes a brain-like navigation scheme to improve the accuracy and ...
Chong Shen, Xiaochen Liu, Huiliang Cao, Yuchen Zhou, Jun Liu, Jun Tang, Xiaoting Guo, Haoqian Huang, Xuemei Chen   +8 more
doaj   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Exchangeable pairs and Poisson approximation

, 2005
This is a survey paper on Poisson approximation using Stein's method of exchangeable pairs. We illustrate using Poisson-binomial trials and many variations on three classical problems of combinatorial probability: the matching problem, the coupon ...
Chatterjee, Sourav, Diaconis, Persi, Meckes, Elizabeth   +2 more
core   +3 more sources

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Improved feature point extraction and mismatch eliminating algorithm

Systems Science & Control Engineering, 2020
For the existing image matching algorithms, some inherent shortcomings, such as high mismatch rate and low computational efficiency, give rise to a bad influence on the performance of Visual Simultaneous Localization and Mapping (VSLAM). In this paper, a
Dongyue Sun, Sunjie Zhang, Yongxiong Wang   +2 more
doaj   +1 more source

Impact of matching error on linked mortality outcome in a data linkage of secondary mental health data with Hospital Episode Statistics (HES) and mortality records in South East London: a cross-sectional study [PDF]

, 2020
Amelia Jewell, Matthew Broadbent, Richard D. Hayes, Ruth Gilbert, Robert Stewart, Johnny Downs   +5 more
openalex   +1 more source

Level and Eigenfunction Statistics in Billiards with Surface Scattering

, 2000
Statistical properties of billiards with diffusive boundary scattering are investigated by means of the supersymmetric sigma-model in a formulation appropriate for chaotic ballistic systems.
A. A. Abrikosov, A. Altland, A. Altland, A. Altland, A. D. Mirlin, A. D. Mirlin, A. D. Mirlin, A. D. Mirlin, A. G. Aronov, A. Kudrolli, A. M. Ozorio de Almeida, A. Szafer, A. V. Andreev, A. V. Andreev, A. V. Andreev, B. A. Muzykantskii, B. A. Muzykantskii, B. A. Muzykantskii, B. D. Simons, B. L. Altshuler, C. W. J. Beenakker, C. W. J. Beenakker, D. E. Khmelnitskii, D. Taras-Semchuk, E. B. Bogomolny, E. Cuevas, E. Louis, E. Louis, E. Louis, F. Borgonovi, H. Alt, I. L. Aleiner, I. L. Aleiner, J. Goldberg, J. Stein, K. B. Efetov, K. Fuchs, K. M. Frahm, K. M. Frahm, K. M. Frahm, K. V. Samokhin, L. P. Kouwenhoven, M. L. Mehta, M. Srednicki, M. V. Berry, M. V. Berry, M. V. Berry, O. Agam, O. Agam, P. Wölfle, R. E. Prange, S. Bjørnholm, S. Hortikar, T. Guhr, V. E. Kravtsov, V. E. Kravtsov, V. I. Fal’ko, V. I. Fal’ko, V. I. Okulov, V. M. Apel, V. N. Prigodin, V. N. Prigodin, V. N. Prigodin, V. Tripathi, Y. V. Fyodorov, Ya. M. Blanter, Ya. M. Blanter, Ya. M. Blanter, Ya. M. Blanter, Yu. N. Ovchinnikov   +69 more
core   +2 more sources

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source