Results 91 to 100 of about 1,015,689 (333)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Generating Cohort-specific Earnings through the Secure Query System

International Journal of Population Data Science
Objectives In collaboration with the U.S. Internal Revenue Service, we are developing a Secure Query System (SQS) to produce earnings and tax statistics for lists of individuals supplied by government agencies or academic institutions.
Amy O'Hara, Stephanie Straus, Jake Pasner   +2 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Heterogeneous Image Matching via a Novel Feature Describing Model

Applied Sciences, 2019
Computer vision has been developed greatly in the past several years, and many useful and interesting technologies have been presented and widely applied. Image matching is an important technology based on similarity measurement.
Bin Zhou, Xuemei Duan, Dongjun Ye, Wei Wei, Marcin Woźniak, Robertas Damaševičius   +5 more
doaj   +1 more source

Large deviations for template matching between point processes

, 2004
We study the asymptotics related to the following matching criteria for two independent realizations of point processes X\sim X and Y\sim Y. Given l>0, X\cap [0,l) serves as a template. For each t>0, the matching score between the template and Y\cap [t,t+
Chi, Zhiyi
core   +3 more sources

Probabilistic models of information retrieval based on measuring the divergence from randomness [PDF]

, 2002
We introduce and create a framework for deriving probabilistic models of Information Retrieval. The models are nonparametric models of IR obtained in the language model approach.
Allan J., Amati G., Bookstein A., Carpineto C., Cornelis Joost Van Rijsbergen, Croft W., Damerau F., Gianni Amati, Harman D., Harter S. P., Harter S. P., Lafferty J., Margulis E., Ponte J., Robertson S., Robertson S., Robertson S. E., Robertson S. E., Solomonoff R., Solomonoff R., van Rijsbergen C.   +20 more
core   +1 more source

Unsupervised Domain Adaptation for Acoustic Scene Classification Using\n Band-Wise Statistics Matching [PDF]

, 2020
Alessandro Ilic Mezza, Emanuël A. P. Habets, Meinard Müller, Sarti, Augusto   +3 more
openalex   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Statistical file matching of flow cytometry data

Journal of Biomedical Informatics, 2011
Flow cytometry is a technology that rapidly measures antigen-based markers associated to cells in a cell population. Although analysis of flow cytometry data has traditionally considered one or two markers at a time, there has been increasing interest in multidimensional analysis.
Lee, Gyemin, Finn, William, Scott, Clayton   +2 more
openaire   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source