Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
PHONI: Streamed Matching Statistics with Multi-Genome References. [PDF]
Proc Data Compress Conf, 2021 Boucher C +8 more
europepmc +1 more source
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
On randomization-based causal inference for matched-pair factorial designs [PDF]
arXiv, 2017 Under the potential outcomes framework, we introduce matched-pair factorial designs, and propose the matched-pair estimator of the factorial effects. We also calculate the randomization-based covariance matrix of the matched-pair estimator, and provide the "Neymanian" estimator of the covariance matrix.
arxiv
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
Match results prediction ability of official ATP singles ranking [PDF]
arXiv, 2017 This paper discusses match result prediction ability of ATP ranking points, which is official ranking points for men's professional tennis players. The structure of overall ATP World Tour and the ranking point attribution system leads that the ranking point ratio between two players is an essential variable.
arxiv
The essential role of balance tests in propensity‐matched observational studies: Comments on ‘A critical appraisal of propensity‐score matching in the medical literature between 1996 and 2003’ by Peter Austin, Statistics in Medicine [PDF]
, 2008 Bjarke Brandt Hansen
openalex +1 more source
Molecular Oncology, EarlyView.TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam +9 more
wiley +1 more source
Unsupervised Domain Adaptation for Acoustic Scene Classification Using Band-Wise Statistics Matching [PDF]
, 2020 Alessandro Ilic Mezza +3 more
openalex +3 more sources