Results 101 to 110 of about 522,025 (259)

Study of guppies’ numerical abilities using the matching-to-sample paradigm.

reservedQuesto studio ha indagato le abilità numeriche in Poecilia reticulata utilizzando il paradigma del Matching-to-Sample (MTS). Le femmine adulte di Poecilia reticulata sono state esposte a stimoli numerici bidimensionali, in relazione ai quali ...
BERTARELLO, MICHAEL
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Propensity Score Matching Methods for Non-experimental Causal Studies [PDF]

This paper considers causal inference and sample selection bias in non-experimental settings in which: (i) few units in the non-experimental comparison group are comparable to the treatment units, and (ii) selecting a subset of comparison units similar ...
Sadek Wahba, Rajeev H. Dehejia
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

EFECTO DE DOS TIPOS DE DESCRIPCIONES PRECONTACTO SOBRE LA EJECUCIÓN INSTRUMENTAL Y DESCRIPCIONES POSCONTACTO EN TAREAS DE IGUALACIÓN DE LA MUESTRA [PDF]

Acta Colombiana de Psicología, 2010
The effects of different kinds of pre-contact descriptions were assessed: a) one specific and pertinent (EP) in the situation components of the stimulus (SE), Response (R), and Consequences (C); and b) one that shows variations about the correct and ...
Ortiz, Gerardo, González, Víctor
doaj  

The Principal-Agent Matching Market [PDF]

We propose a model based on competitive markets in order to analyse an economy with several principals and agents. We model the principal-agent economy as a two-sided matching game and characterise the set of stable outcomes of this principal-agent ...
Kaniska Dam
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Estimating Causal Effects with Matching Methods in the Presence and Absence of Bias Cancellation [PDF]

This paper explores the implications of possible bias cancellation using Rubin-style matching methods with complete and incomplete data. After reviewing the naïve causal estimator and the approaches of Heckman and Rubin to the causal estimation problem ...
Henriette Engelhardt, Thomas A. DiPrete
core   +2 more sources

Investigation of rule control by controlling the effetcts of reinforcement history on human behavior / Investigação do controle por regras e do controle por histórias de reforço sobre o comportamento humano

Psicologia: Reflexão e Crítica, 2004
This study investigated the role of experimental history and of relative density of reinforcement on rule following behavior. Sixteen undergraduate students participated.
Luiz Carlos de Albuquerque, Maria Amélia Matos, Deisy das Graças de Souza, Carla Cristina Paiva Paracampo   +3 more
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source