Results 131 to 140 of about 2,631 (192)

ToxPoint: The case for Equilibrative Nucleoside Transporters in current regulatory guidance. [PDF]

Toxicol Sci
Martinez-Guerrero L, Tang X, Ekins S, Wright SH, Cherrington NJ.   +4 more
europepmc   +1 more source

Old Drug, New Science: Metformin and the Future of Pharmaceutics. [PDF]

Pharmaceutics
Caturano A, Nilo D, Nilo R, Sircana MC, Erul E, Zielińska K, Russo V, Santonastaso E, Sasso FC.   +8 more
europepmc   +1 more source

Drug-drug interactions in targeted cancer therapies: a focus on tyrosine kinase inhibitors. [PDF]

Expert Rev Clin Pharmacol
Stromatt JC, Chowdhury AT, Huang KM, Hu S, Sparreboom A, Baker SD, Eisenmann ED.   +6 more
europepmc   +1 more source

Metformin in Colorectal Cancer: Epidemiological Evidence, Predictive Biomarkers, and Implications for Prevention and Treatment. [PDF]

Int J Mol Sci
Myung S, Park YY, Kim MS.
europepmc   +1 more source

The Effect of MATE1 Polymorphisms on Cisplatin Efficacy in the Treatment of Head and Neck Cancer

International Journal of Radiation Oncology*Biology*Physics, 2018
Mahler, M, Teft, W, Breadner, D, Bukhari, N, Kuruvilla, S, Nichols, A, Palma, D.A., Kim, R, Winquist, E   +8 more
openaire   +3 more sources

Predicting OCT2/MATEs-Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium). [PDF]

Clin Pharmacol Ther
Asano S, Galetin A, Tomita Y, Giacomini KM, Chu X, Yang X, Nakamura T, Kusuhara H, Sugiyama Y.   +8 more
europepmc   +1 more source

Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity.

Disruption of multidrug and toxin extrusion MATE1 potentiates cisplatin-induced nephrotoxicity.
Multidrug and toxin extrusion 1 (MATE1/SLC47A1) is expressed in the brush-border membrane of renal proximal tubules and mediates the efflux of cationic drugs. In the present study, the role of MATE1 in the nephrotoxicity of cisplatin was investigated in vivo and in vitro.
openaire  

A strategy for evaluating the impact of processing of Chinese meteria medica on meridian tropism: the influence of salt-water processing of phellodendri chinensis cortex on renal transport proteins. [PDF]

Front Pharmacol
Chen Y, Zhang F, Ren W, Zhou Y, Jiang S, Zhang S, Xu G, Ge X, Gao H.   +8 more
europepmc   +1 more source

Characterization of Drug-Drug Interactions for Remdesivir, an Intravenous Antiviral for SARS-CoV-2, in Healthy Participants. [PDF]

Clin Transl Sci
Chang J, Kim A, Humeniuk R, Shaik NA, Winter H, Peng CC, Xiao D, Abdelghany M, Llewellyn J, Davies S, Golden K, Chen S, Hyland RH, Caro L.   +13 more
europepmc   +1 more source

Safety and Effectiveness Analysis of Dolutegravir and Dolutegravir/Abacavir/Lamivudine in Japanese People Living with HIV: 10 years of Post-Marketing Surveillance. [PDF]

Adv Ther
Sebata A, Nagao T, Matsukawa T, Maeno Y, Suzuki M, Yoshikawa Y, Ibe S, Fukuda A, Wang D.   +8 more
europepmc   +1 more source