Multi-omics reveal molecular changes during suspension adaptation of HEK293 cells [PDF]
Applied Microbiology and BiotechnologyHuman embryonic kidney 293 (HEK293) cells have been successfully adapted from adherent to suspension culture and widely applied in both scientific research and the pharmaceutical industry.
Benyao Zhang +9 more
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Antioxidant Efficacy of Esculetin against Tert-Butyl Hydroperoxide-Induced Oxidative Stress in HEK293 Cells [PDF]
Current Issues in Molecular Biology, 2022 Esculetin is an antioxidant and anti-inflammatory compound derived from coumarin. Oxidative stress can cause overproduction of reactive oxygen species (ROS), which can lead to the development of chronic kidney failure.
Woo Kwon Jung +4 more
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MicroRNA and Hemophilia-A Disease: Bioinformatics Prediction and Experimental Analysis [PDF]
Cell Journal, 2021 Objective: Hemophilia-A is a common genetic abnormality resulted from decreased or lack of factor VIII (FVIII) pro-coagulant protein function caused by mutations in the F8 gene.
Halimeh Rezaei +2 more
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Kidney Diseases, 2022 Introduction: Acute kidney injury (AKI) is a major public health problem worldwide. However, there is no definitive therapies to treat established AKI. In this study, we used FG-4592 to induce hypoxia inducible factor (HIF) expression in cells and then ...
Zhao-Ying Ding +7 more
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Distinct mechanical behavior of HEK293 cells in adherent and suspended states [PDF]
PeerJ, 2015 The mechanical features of individual animal cells have been regarded as indicators of cell type and state. Previously, we investigated the surface mechanics of cancer and normal stromal cells in adherent and suspended states using atomic force ...
Seyed Mohammad Ali Haghparast +2 more
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Latent membrane protein 1 is dispensable for Epstein-Barr virus replication in human embryonic kidney 293 cells. [PDF]
PLoS ONE, 2011 Epstein Barr Virus (EBV) replicates in oral epithelial cells and gains entry to B-lymphocytes. In B-lymphocytes, EBV expresses a restricted subset of genes, the Latency III program, which converts B-lymphocytes to proliferating lymphoblasts.
Vicki Geiser +2 more
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A Comparative Study on the Efficiency of CRISPR-Cas9 in Human Embryonic Kidney 293 Cells and Peripheral Blood Mononuclear Cells for Disruption in Programmed Cell Death Protein 1 [PDF]
Journal of Genetic Resources, 2022 CRISPR-Cas9 is the most important tool in genome engineering in recent years. The efficiency of this instrument on active and non-active genes is variable.
Seyed Ali Alambeladi +2 more
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Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-α. [PDF]
PLoS ONE, 2011 Helicobacter pylori is the causative agent for developing gastritis, gastric ulcer, and even gastric cancer. Virulent strains carry the cag pathogenicity island (cagPAI) encoding a type-IV secretion system (T4SS) for injecting the CagA protein.
Suneesh Kumar Pachathundikandi +3 more
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Human concentrative nucleoside transporter 3 transfection with ultrasound and microbubbles in nucleoside transport deficient HEK293 cells greatly increases gemcitabine uptake. [PDF]
PLoS ONE, 2013 Gemcitabine is a hydrophilic clinical anticancer drug that requires nucleoside transporters to cross plasma membranes and enter cells. Pancreatic adenocarcinomas with low levels of nucleoside transporters are generally resistant to gemcitabine and are ...
Robert J Paproski +6 more
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Effect of Quercetin on Injury to Indomethacin-Treated Human Embryonic Kidney 293 Cells
Life, 2021 Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat inflammation and pain and even to prevent the progression of cardiovascular disease. They have become widely used because of their effectiveness, especially among athletes performing high ...
Chun Chen +4 more
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